Risk of recurrence after a first unprovoked seizure
Risk of recurrence after a first unprovoked seizure
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DOI：
10.1111/j.1528-1167.2008.01444.x
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发表时间：
2008-01-01
期刊：
影响因子：
5.6
通讯作者：
Berg, Anne T.
中科院分区：
文献类型：
--
作者：
Berg, Anne T.
第一次无端癫痫发作后复发的风险已经在许多观察性研究和两项大型高质量随机试验中进行了研究。总的来说，在未经治疗的个体中，40-50%的人可以预期在首次癫痫发作后2年内复发。治疗可以将这种风险降低一半。那些复发风险最大的患者要么脑电图异常，要么有可识别的神经系统疾病或症状（“症状”）。癫痫持续状态和热性惊厥史可能与症状性惊厥复发风险增加有关。绝大多数人（约90%）首次无故癫痫发作的患者在首次发作后的4或5年内获得一到两年的缓解。
The risk of recurrence after a first unprovoked seizure has been examined in numerous observational studies and two large, high-quality randomized trials. Overall, in untreated individuals, 40-50% can expect a recurrence within 2 years of the initial seizure. Treatment may reduce this risk by as much as half. Those at the greatest risk of recurrence have either an abnormal EEG or an identifiable neurological condition or symptoms consistent with one ("symptomatic"). Status epilepticus and a history of febrile seizures may be associated with an increased risk of recurrence in individuals with symptomatic seizures. The great majority of people (similar to 90%) who are seen for a first unprovoked seizure attain a one to two year remission within 4 or 5 years of the initial event.