Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy
Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy
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DOI：
10.1016/j.fertnstert.2012.06.011
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发表时间：
2012-10-01
影响因子：
6.7
通讯作者：
Tanbo, Tom G.
中科院分区：
文献类型：
--
作者：
Eskild, Anne;Fedorcsak, Peter;Tanbo, Tom G.
目的：探讨孕妇孕前体重指数（BMI）与妊娠早期血清hCG浓度的关系。设计：横断面研究。地点：挪威奥斯陆大学医院，1996-2010年。患者：在3301例通过辅助生殖技术孕育活产后代的孕妇中，2611名妇女有促排卵后第16天血清hCG浓度和孕前BMI信息：2110名单胎母亲和501名多胎母亲。干预:没有。主要观察指标：人绒毛膜促性腺激素浓度。结果：多胎妊娠hCG几何平均浓度（190 IU/L）高于单胎妊娠（106 IU/L）。在单胎妊娠中，BMI = 35 kg/m的女性几何平均血清浓度从117 IU/L下降(2)。在多胎妊娠中，相应的从226 IU/L下降到130 IU/L。BMI与hCG浓度对数变换在研究样本整体（回归系数-0.013）、单胎妊娠（回归系数-0.012）和多胎妊娠（回归系数-0.03）中呈显著负相关。结论：血清hCG浓度与孕妇孕前BMI呈负相关。一种可能的解释可能是脂肪组织来源的信号分子对植入胚胎分泌hCG的影响。[j] .中国农业科学（英文版），2012;28(5):391 - 391。(C) 2012年，美国生殖医学学会。)
Objective: To study the association of maternal prepregnancy body mass index (BMI) with serum concentrations of hCG in early pregnancy.Design: Cross-sectional study.Setting: Oslo University Hospital, Norway, 1996-2010.Patient(s): Among 3,301 pregnancies with live-born offspring conceived after assisted reproductive techniques, 2,611 women had information on serum hCG concentrations on day 16 after ovulation induction and prepregnancy BMI: 2,110 mothers with singleton and 501 mothers with multiple pregnancy.Intervention(s): None.Main Outcome Measure(s): Human chorionic gonadotropin concentration.Result(s): Geometric mean hCG concentration was higher in multiple pregnancies (190 IU/L) than in singleton pregnancies (106 IU/L). In singleton pregnancies geometric mean serum concentration decreased from 117 IU/L in women with BMI = 35 kg/m(2). In multiple pregnancies, the corresponding decrease was from 226 IU/L to 130 IU/L. There was a significant negative association of BMI with hCG concentrations log transformed in the study sample as a whole (regression coefficient -0.013), in singleton pregnancies (regression coefficient -0.012), and in multiple pregnancies (regression coefficient -0.03).Conclusion(s): Serum hCG concentrations were negatively associated with maternal prepregnancy BMI. One possible explanation may be an effect of adipose tissue-derived signaling molecules on hCG secretion by the implanting embryo. (Fertil Steril (R) 2012;98:905-10. (C) 2012 by American Society for Reproductive Medicine.)