Symptom relief, prognostic factors, and outcome in patients receiving urgent radiation therapy for superior vena cava syndrome : A single-center retrospective analysis of 21 years' practice.
Symptom relief, prognostic factors, and outcome in patients receiving urgent radiation therapy for superior vena cava syndrome : A single-center retrospective analysis of 21 years' practice.
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DOI：
10.1007/s00066-022-01952-z
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发表时间：
2022-12
影响因子：
3.1
通讯作者：
Rieken, Stefan
中科院分区：
文献类型：
--
作者：
Guhlich, Manuel;Maag, Teresa Esther;Droege, Leif Hendrik;El Shafie, Rami A.;Hille, Andrea;Donath, Sandra;Schirmer, Markus Anton;Knaus, Olga;Nauck, Friedemann;Overbeck, Tobias Raphael;Hinterthaner, Marc;Koerber, Wolfgang;Andreas, Stefan;Rittmeyer, Achim;Leu, Martin;Rieken, Stefan
上腔静脉综合征（SVCS）通常由肿瘤生长引起的外血管压迫引起。紧急症状引导放射治疗（RT）仍然是组织学证实的快速进展疾病的主要治疗方法。尽管有一些出版物，最近关于症状缓解和肿瘤结果以及治疗反应的潜在混杂因素的数据仍然很少。我们对2000年至2021年 在大学医学中心Göttingen接受紧急RT治疗的患者进行了回顾性单中心分析。以CTCAE评分评估患者在放疗过程中的症状缓解程度。采用logistic回归评估各变量对症状缓解的影响。采用Kaplan-Meier图、log-rank检验和Cox回归分析评估各参数对总生存期（OS）的影响。在多变量分析中检验了具有统计学意义（p值 < 0.05）的混杂因素。共纳入79例患者。68.4%的患者症状得到缓解。平均生存期为59天，7.6% （n = 6）的患者长期生存（> 2年）。应用放射治疗剂量> 39 Gy，临床靶体积（CTV）大小< 387 ml，伴随化疗，完成规定的放射治疗疗程对OS有统计学意义；应用放射治疗剂量和完成规定的放射治疗疗程对症状缓解有统计学意义。大多数SVCS患者通过紧急RT获得症状缓解。RT剂量和RT疗程的完成情况被记录为OS和症状缓解的预测因素，CTV < 387 ml和伴随化疗是OS的预测因素。本文的在线版本（10.1007/s00066-022-01952-z）包含补充资料，仅供授权用户使用。
Superior vena cava syndrome (SVCS) often results from external vessel compression due to tumor growth. Urgent symptom-guided radiotherapy (RT) remains a major treatment approach in histologically proven, rapidly progressive disease. Despite several publications, recent data concerning symptom relief and oncological outcome as well as potential confounders in treatment response are still scarce. We performed a retrospective single-center analysis of patients receiving urgent RT between 2000 and 2021 at the University Medical Center Göttingen. Symptom relief was evaluated by CTCAE score during the RT course. Effects of variables on symptom relief were assessed by logistic regression. The impact of parameters on overall survival (OS) was evaluated using Kaplan–Meier plot along with the log-rank test and by Cox regression analyses. Statistically significant (p-value < 0.05) confounders were tested in multivariable analyses. A total of 79 patients were included. Symptom relief was achieved in 68.4%. Mean OS was 59 days, 7.6% (n = 6) of patients showed long-term survival (> 2 years). Applied RT dose > 39 Gy, clinical target volume (CTV) size < 387 ml, concomitant chemotherapy, and completion of the prescribed RT course were found to be statistically significant for OS; applied RT dose and completion of the prescribed RT course were found to be statistically significant for symptom relief. Symptom relief by urgent RT for SVCS was achieved in the majority of patients. RT dose and completion of the RT course were documented as predictors for OS and symptom relief, CTV < 387 ml and concomitant chemotherapy were predictive for OS. The online version of this article (10.1007/s00066-022-01952-z) contains supplementary material, which is available to authorized users.
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影响因子：
15.1
作者：
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通讯作者：
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DOI：
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影响因子：
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作者：
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影响因子：
3.1
作者：
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