CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis
CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis
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DOI：
10.1016/j.clim.2006.11.004
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发表时间：
2007-04-01
影响因子：
8.6
通讯作者：
Du Pasquier, Renaud A.
中科院分区：
文献类型：
--
作者：
Jilek, Samantha;Schluep, Myriam;Du Pasquier, Renaud A.
CD 8 + T细胞可能在多发性硬化（MS）中发挥重要作用。我们招募了52名疑似MS的患者，确定了CSF中与外周血相比的高度分化（CCR 7-/CD 45 RA+或-）T细胞（T（HD））的募集，并对他们进行了12 +/-7.3个月的随访。ROC曲线显示，0.94的CD 8 +/CD 4 + T（HD）细胞比率有助于区分复发缓解型（RR-MS）和可能MS（Po-MS）与原发-进展型MS（PP-MS）和其他神经系统疾病患者（OND）患者（p=0.039），风险比为2.29（95%CI：1.13-4.66; p = 0.039）。006）。在RR/Po-MS患者中，CD 8 + THD细胞中的CSF富集大于CD 4 + THD细胞中的CSF富集（p=0.024），并且在PP-MS/OND细胞中，CSF富集大于CD 8 + THD细胞中的CSF富集（p=0.006）。这些数据表明，CD 8 + T（HD）RR-MS。（c）2006 Elsevier Inc. All rights reserved.
CD8+ T cells may play an important rote in multiple sclerosis (MS). Whether these cells would be involved in early stages of MS is unclear.We enrolled 52 patients with suspected MS, determined the recruitment of their highly differentiated (CCR7-/CD45RA+ or -) T cells (T(HD)) in the CSF as compared to peripheral blood and followed them for 12 +/- 7.3 months. A ROC curve showed that a CD8+/CD4+ T(HD) cells ratio of 0.94 helped to distinguish relapsing-remitting (RR-MS) and possible MS (Po-MS) from primary-progressive MS (PP-MS) and other neurological diseases patients (OND) patients (p=0.039), risk ratio of 2.29 (95% CI: 1.13-4.66; p = 0. 006). The CSF enrichment in CD8+ THD cells was greater than in CD4+ THD cells in RR/Po-MS patients (p=0.024) and than in CD8+ THD cells in PP-MS/OND cells play a role in the early stages of patients (p=0.006). These data suggest that CD8+ T(HD) RR-MS. (c) 2006 Elsevier Inc. All rights reserved.