Assessing footprints of selection in commercial Atlantic salmon populations using microsatellite data
Assessing footprints of selection in commercial Atlantic salmon populations using microsatellite data
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DOI：
10.1111/j.1365-2052.2012.02387.x
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发表时间：
2013-04-01
期刊：
影响因子：
2.4
通讯作者：
Davidson, W. S.
中科院分区：
文献类型：
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作者：
Martinez, V.;Dettleff, P.;Davidson, W. S.
在鲑鱼的不同选择实验中，观察到对经济重要性性状的反应率相对较大。在鲑鱼基因组中已经定位了几个QTL，解释了前所未有的表型变异水平。由于相对较大的选择强度，个体基因座可能被间接选择，留下选择的分子足迹，以及增加的近亲繁殖，因为其可能的亲属将共享所选择的基因座。我们使用的人口分化和水平的连锁不平衡的染色体，已知窝藏QTL体重，传染性胰腺坏死抗性和传染性鲑鱼贫血抗性，以评估最近的选择历史在基因组水平在大西洋鲑鱼。结果表明，位于第3染色体上的标记SSA0343BSFU（体重QTL）显示了定向选择的有力证据。有趣的是，该标记被物理定位到DVL 2编码序列附近的区域，使其成为解释该染色体对萨尔莫盐沼生长选择的快速进化反应的理想候选基因。在与传染性胰腺坏死和传染性鲑鱼贫血抗性相关的QTL中观察到多样化选择的微弱证据。总的来说，这项研究表明，人工选择产生了重要的变化，在大西洋鲑鱼基因组，验证QTL的商业鲑鱼种群用于生产目的，根据最近的选择历史。
Relatively large rates of response to traits of economic importance have been observed in different selection experiments in salmon. Several QTL have been mapped in the salmon genome, explaining unprecedented levels of phenotypic variation. Owing to the relatively large selection intensity, individual loci may be indirectly selected, leaving molecular footprints of selection, together with increased inbreeding, as its likely relatives will share the selected loci. We used population differentiation and levels of linkage disequilibrium in chromosomes known to be harbouring QTL for body weight, infectious pancreatic necrosis resistance and infectious salmon anaemia resistance to assess the recent selection history at the genomic level in Atlantic salmon. The results clearly suggest that the marker SSA0343BSFU on chromosome 3 (body weight QTL) showed strong evidence of directional selection. It is intriguing that this marker is physically mapped to a region near the coding sequence of DVL2 , making it an ideal candidate gene to explain the rapid evolutionary response of this chromosome to selection for growth in Salmo salar. Weak evidence of diversifying selection was observed in the QTL associated with infectious pancreatic necrosis and infectious salmon anaemia resistance. Overall, this study showed that artificial selection has produced important changes in the Atlantic salmon genome, validating QTL in commercial salmon populations used for production purposes according to the recent selection history.