Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI
Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI
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DOI：
10.1038/s41467-019-11319-1
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发表时间：
2019-07-30
影响因子：
16.6
通讯作者：
Mezer, Aviv A.
中科院分区：
文献类型：
--
作者：
Filo, Shir;Shtangel, Oshrat;Mezer, Aviv A.
这是一个悬而未决的问题，整个大脑中与衰老相关的变化是由一个共同的因素驱动的，还是由几个不同的分子机制引起的。定量磁共振成像（qMRI）提供了生物物理参数测量，允许非侵入性映射老化的人脑。然而，qMRI测量值随分子组成和含水量的变化而变化。在这里，我们提出了一种组织弛豫的方法，解开这两个组织成分和解码的分子信息的MRI信号。我们的方法使我们能够揭示脂质样品的分子组成，并预测大脑的脂质组学测量。它在整个大脑中产生独特的分子特征，这些分子特征与特定的基因表达谱相关。我们揭示了与大脑衰老相关的区域特异性分子变化。这些变化独立于其他MRI老化标志物。我们的方法打开了一扇大门，定量表征的生物来源的老化，到目前为止，可能只有死后。
It is an open question whether aging-related changes throughout the brain are driven by a common factor or result from several distinct molecular mechanisms. Quantitative magnetic resonance imaging (qMRI) provides biophysical parametric measurements allowing for non-invasive mapping of the aging human brain. However, qMRI measurements change in response to both molecular composition and water content. Here, we present a tissue relaxivity approach that disentangles these two tissue components and decodes molecular information from the MRI signal. Our approach enables us to reveal the molecular composition of lipid samples and predict lipidomics measurements of the brain. It produces unique molecular signatures across the brain, which are correlated with specific gene-expression profiles. We uncover region-specific molecular changes associated with brain aging. These changes are independent from other MRI aging markers. Our approach opens the door to a quantitative characterization of the biological sources for aging, that until now was possible only post-mortem.