Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders
Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders
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DOI：
10.1111/pcn.12210
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发表时间：
2015-03-01
影响因子：
11.9
通讯作者：
Minabe, Yoshio
中科院分区：
文献类型：
--
作者：
Hasegawa, Chiaki;Kikuchi, Mitsuru;Minabe, Yoshio
AimsThe的目的是本研究的目的是确定表型的母亲和父亲，特别是与干扰的相互社会交往和沟通，在他们的幼儿与自闭症谱系障碍（ASD）在日本sample.MethodsAutistic特质的父母进行了评估，使用自闭症谱系商数（AQ），对88名ASD患儿父母（母亲44名，父亲30名）和60名正常发育（TD）患儿父母（母亲30名，父亲30名）的情商（EQ）和系统商（SQ）进行了测定。自闭症儿童的特征的测量，我们采用的社会反应量表（SRS）。ResultsIn两个的五个AQ分量表（社会技能和沟通），ASD儿童的父母得分显着高于TD儿童的父母，无论父母是母亲还是父亲。此外，在ASD儿童的母亲中，五个AQ分量表中有两个分量表之间存在显著正相关（注意力转换和沟通）和SRST-结论这是第一项研究表明，社会技能和沟通分量表中的社会技能和沟通分量表更敏感的自闭症特征在日本样本，并证明一些自闭症特征的母亲是特别相关的，他们患有ASD的幼儿的社会能力障碍，如SRS评分所测量的。进一步的研究是必要的，以确定这些结果是由遗传或环境因素引起的。
AimsThe aim of this study was to identify phenotypes in mothers and fathers that are specifically associated with disturbances in reciprocal social interactions and communication in their young children with autism spectrum disorder (ASD) in a Japanese sample.MethodsAutistic traits in parents were evaluated using the Autism-spectrum Quotient (AQ), the Empathy Quotient (EQ) and the Systemizing Quotient (SQ) in 88 parents (44 mothers and corresponding fathers) of children with ASD and in 60 parents (30 mothers and corresponding fathers) of typically developing (TD) children. For the measurement of autistic traits in children, we employed the Social Responsiveness Scale (SRS).ResultsIn two of the five AQ subscales (social skills and communication), the parents of ASD children scored significantly higher than did the parents of TD children, regardless of whether the parent was a mother or a father. In addition, in mothers of ASD children, there were significant positive correlations between two of the five AQ subscales (attention-switching and communication) and the SRST-score in their children.ConclusionsThis is the first study to demonstrate that the social skills and communication subscales in the AQ are more sensitive as autism traits in a Japanese sample and to demonstrate that some autistic traits in mothers are specifically associated with disturbances in the social ability of their young children with ASD, as measured by the SRS score. Further study is necessary to determine whether these results were caused by genetic or environmental factors.