Aortic vascular calcification is inversely associated with the trabecular bone score in patients receiving dialysis
Aortic vascular calcification is inversely associated with the trabecular bone score in patients receiving dialysis
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DOI：
10.1016/j.bone.2018.05.014
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发表时间：
2018-08-01
期刊：
影响因子：
4.1
通讯作者：
Elder, Grahame J.
中科院分区：
文献类型：
--
作者：
Aleksova, Jasna;Kurniawan, Samantha;Elder, Grahame J.
Introduction: Progressive chronic kidney disease (CKD) confers a marked increase in risk for vascular calcification, cardiovascular disease, fracture and mortality, with likely contributing factors including dysregulated bone metabolism and mineral homeostasis. In general population studies, increased vascular calcification is directly related to mortality and inversely related to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). In patients with CKD, abnormalities in turnover, mineralization and bone volume reduce the ability of DXA to predict fracture. The trabecular bone score (TBS) obtained from lumbar spine DXA images, provides a surrogate measure of microarchitectural integrity not captured by BMD. This study aimed to examine the association of the TBS to prevalent abdominal aortic calcification (AAC) in patients with CKD receiving dialysis.Methods: We performed a cross-sectional study of dialysis patients awaiting transplantation. All patients underwent laboratory testing, lateral spinal radiographs including the abdominal aorta, DXA imaging and TBS assessment. AAC scores were determined using the Kauppila method. Correlations and linear regression models were used to determine predictors of AAC scores.Results: 146 patients (60% male, mean age 48 +/- 13 years) were included, of whom 49% had prevalent calcification with an AAC score >= 1. Of those with calcification, the mean AAC score was 7 +/- 5.5 and 42 patients had scores >= 6, considered to indicate severe AAC. TBS values corresponding to intermediate or high risk for fracture (
