Molecular chaperones: Pathways and networks

Molecular chaperones: Pathways and networks
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DOI:
10.1016/s0960-9822(99)80082-7
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发表时间:
1999-02
期刊:
影响因子:
9.2
通讯作者:
R. Ellis
R. Ellis
中科院分区:
生物学1区
文献类型:
--
作者:
R. Ellis

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生长中的真核细胞合成的一些蛋白质沿着分子伴侣的单向路径转移,直到聚集的风险降低,它们可以安全释放。相反,因应激而变性的成熟蛋白质可能由分支的可逆网络中的伴侣来处理。
Some proteins synthesized by growing eukaryotic cells are transferred along unidirectional pathways of molecular chaperones until the risk of aggregation has decreased and they can be released safely. Mature proteins denatured by stress may instead be handled by chaperones acting in branched, reversible networks.