Local Delivery of Hyaluronan as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis
Local Delivery of Hyaluronan as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis
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DOI：
10.1902/jop.2009.090128
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发表时间：
2009-09-01
影响因子：
4.3
通讯作者：
Johannsen, Gunnar
中科院分区：
文献类型：
--
作者：
Johannsen, Annsofi;Tellefsen, Monica;Johannsen, Gunnar
背景：本研究的目的是评估局部应用透明质酸凝胶治疗慢性牙周炎的辅助效果。方法：招募12例慢性牙周炎患者参与一项分口设计的研究，并提供知情同意书。在治疗前（基线）、治疗后1周、4周和12周评估探针上的斑块形成和出血情况。在基线和12周时评估探针深度和附着水平。患者接受全口洗牙和牙根刨平。在基线和1周后，在测试部位龈下给予透明质酸凝胶。使用配对t检验、重复测量方差分析（Wilks lambda）和非参数Wilcoxon符号秩检验来评估测试和对照之间的显著差异。结果：两组患者12周时探针评分及探针深度出血均显著减少（P < 0.05）。12周时，透明质酸组与对照组相比，穿刺评分出血明显减少（P < 0.05）。在基线和12周之间，透明质酸组和对照组的平均探深减少分别为1.0 +/- 0.3 mm和0.8 +/- 0.2 mm。两组间差异有统计学意义（P < 0.05）。结论：局部应用透明质酸凝胶配合洗牙和牙根平整对慢性牙周炎患者的牙周健康有益。中华牙周病杂志；2009;28(3):393 - 397。
Background: The aim of the present study was to evaluate the adjunctive effect of the local application of a hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis.Methods: Twelve patients with chronic periodontitis were recruited to participate in a study with a split-mouth design and provided informed consent. Plaque formation and bleeding on probing were evaluated pretreatment (baseline) and at 1, 4, and 12 weeks post-treatment. Probing depths and attachment levels were evaluated at baseline and at 12 weeks. The patients received full-mouth scaling and root planing. A hyaluronan gel was administered subgingivally in the test sites at baseline and after 1 week. Significant differences between test and control were evaluated using the paired t test, repeated-measures analysis of variance (Wilks lambda), and a non-parametric Wilcoxon signed-rank test.Results: A significant reduction in bleeding on probing scores and probing depths was observed in both groups at 12 weeks (P < 0.05). Significantly lower bleeding on probing scores were observed in the hyaluronan group compared to control at 12 weeks (P < 0.05). Mean probing depth reductions between baseline and 12 weeks were 1.0 +/- 0.3 mm and 0.8 +/- 0.2 mm for the hyaluronan and control groups, respectively. The difference between the groups was statistically significant (P < 0.05).Conclusion: The local application of hyaluronan gel in conjunction with scaling and root planing may have a beneficial effect on periodontal health in patients with chronic periodontitis. J Periodontot 2009;80:1493-1497.