Gadolinium-Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System
Gadolinium-Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System
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掺钆氧化铁纳米探针作为多功能生物成像剂和药物输送系统
DOI：
10.1002/adfm.201502868
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Zhengyan Wu
中科院分区：
文献类型：
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作者：
Guilong Zhang;Ruohong Du;Lele Zhang;Dongqing Cai;Xiao Sun;Yong Zhou;Jian Zhou;Junchao Qian;Kai Zhong;Kang Zheng;Darnell Kaigler;Wenqing Liu;Xin Zhang;Duohong Zou;Zhengyan Wu
在这项研究中，开发了一种高性能的掺杂钆氧化铁纳米颗粒（GION）的cet1 - t2双模型造影剂。随着该药物的开发，我们将探索该药物在体内联合阿霉素（DOX）和叶酸（FA - gion - DOX）靶向给药监测癌症治疗的应用。Gd/Fe比为1/4时，GION的横向和纵向弛豫度分别为182.7 × 10−3和7.87 × 10−3m−1s−1。FA - gion - DOX释放的DOX是pH依赖性的，只有在FA受体介导的内化进入内体和溶酶体的酸性环境后才能杀死癌细胞。在人宫颈癌异种移植模型中，FA-GION-DOX全身递送显著抑制肿瘤生长，并显示出良好的磁共振增强。因此，FA-GION-DOX在宫颈癌的靶向和磁共振成像引导治疗中具有潜在的应用价值。
In this study, a high‐performanceT1–T2dual‐model contrast agent by gadolinium‐doped iron oxide nanoparticle (GION) is developed. Following its development, the application of this agent in vivo by combining doxorubicin (DOX) and folic acid (FA) (FA–GION–DOX) for targeted drug delivery to monitor cancer treatment is explored. GION showed transverse and longitudinal relaxivities up to 182.7 × 10−3and 7.87 × 10−3m−1s−1, respectively, upon Gd/Fe ratio in GION at 1/4. DOX released from FA–GION–DOX is pH dependent and only kills cancer cell after FA receptor‐mediated internalization into the acidic environment of endosomes and lysosomes. Systemic delivery of FA–GION–DOX significantly inhibits the growth of tumors and shows good magnetic resonance enhancement in a human cervical cancer xenograft model. Thus, FA–GION–DOX has a potential application for the targeted and magnetic resonance imaging guided therapy of cervical cancer.