Clinical, virological and histological implications of GB virus-C/hepatitis G virus infection in patients with chronic hepatitis C virus infection: a multicentre study based on 671 patients.
Clinical, virological and histological implications of GB virus-C/hepatitis G virus infection in patients with chronic hepatitis C virus infection: a multicentre study based on 671 patients.
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GB 病毒-C/肝炎病毒感染对慢性丙型肝炎病毒感染患者的临床、病毒学和组织学影响：一项基于 671 名患者的多中心研究。
DOI：
10.1046/j.1365-2893.2000.00188.x
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Lau,JY
中科院分区：
文献类型：
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作者：
Slimane,SB;Albrecht,JK;Fang,JW;Goodman,Z;Mizokami,M;Qian,K;Lau,JY
为了确定GB病毒C/ G型肝炎病毒（GBC - C/HGV）在慢性丙型肝炎病毒（HCV）感染患者中的流行程度，以及临床、病毒学和组织学意义，我们使用敏感和特异性的逆转录“巢式”聚合酶链反应（RT-nPCR）对671例慢性丙型肝炎病毒感染患者的血清进行了GBV - C/HGV RNA检测。671例慢性HCV感染患者中有65例（9.7%）检测到GBV‐C/HGV RNA。重要的是，GBV - C/HGV共感染与肝脏疾病指标的任何变化无关，包括血清丙氨酸转氨酶水平、Knodell评分或组织学活性指数（HAI）。在该队列中，GBV - C/HGV共感染与较短的平均估计HCV感染持续时间和较高的中位HCV病毒血症水平弱相关。我们的结论是，GBV - C/HGV对慢性HCV感染患者的肝脏疾病活动影响很小或没有影响。这些数据支持GBV - C/HGV可能不是肝炎病毒的观点。
To determine the prevalence, as well as the clinical, virological and histological implications of GB virus C/hepatitis G virus (GBC‐C/HGV) infection in patients with chronic hepatitis C virus (HCV) infection, sera from 671 well‐characterized patients with chronic HCV infection were tested for GBV‐C/HGV RNA using a sensitive and specific reverse transcription ‘nested’ polymerase chain reaction (RT–nPCR). GBV‐C/HGV RNA was detected in 65 of 671 (9.7%) patients with chronic HCV infection. Importantly, GBV‐C/HGV co‐infection was not associated with any changes in indices of liver diseases, including serum alanine transaminase levels, Knodell score or histology activity index (HAI). In this cohort, GBV‐C/HGV co‐infection was weakly associated with a shorter mean estimated duration of HCV infection and a higher median HCV viraemia level. We conclude that GBV‐C/HGV has minimal or no impact on liver disease activity in patients with chronic HCV infection. This data supports the notion that GBV‐C/HGV may not be a hepatitis virus.