Prognostic value of EZH2 expression and activity in renal cell carcinoma: a prospective study.
Prognostic value of EZH2 expression and activity in renal cell carcinoma: a prospective study.
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EZH2 表达和活性在肾细胞癌中的预后价值：一项前瞻性研究
DOI：
10.1371/journal.pone.0081484
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Guo J
中科院分区：
文献类型：
--
作者：
Liu L;Xu Z;Zhong L;Wang H;Jiang S;Long Q;Xu J;Guo J
EZH2 表达增加与各种恶性肿瘤的侵袭性临床行为相关。在本研究中，我们旨在探讨肿瘤组织中EZH2表达和活性的临床和预后价值，并改善肾细胞癌术后患者的风险分层。我们分析了我们研究所 373 名肾细胞癌患者的 EZH2 表达及其活性，如 H3K27me3 水平所示。使用 Kaplan-Meier 分析将结果评估为总生存期和无病生存期。通过 Cox 回归分析评估 EZH2 和 H3K27me3 表达对临床结果的预后价值。我们使用接受者操作特征来计算诊断准确性。 EZH2 高表达与所有患者的不良总生存期相关，尤其是晚期 RCC，这是无病生存期和总生存期的独立预后因素。与EZH2相比，H3K27me3表达并不是独立的预后因素。 H3K27me3 和 EZH2 的表达并不完全一致，这可能是由于 Polycomb 阻遏复合体 2 复杂的相互作用所致。在两组无病生存期和总生存期中，EZH2 表达和 TNM 分期的组合比单独 TNM 分期或 EZH2 表达具有更好的预后价值。这些结果表明，评估肿瘤内 EZH2 密度可能会提高 TNM 分期系统的预后价值，并为晚期肾细胞癌患者的治疗决策提供信息。
Increased expression of EZH2 correlates with aggressive clinical behavior in various malignancies. In this study, we aim to investigate the clinical and prognostic values of EZH2 expression and activity in tumor tissues and improve the risk stratification in patients with renal cell carcinoma after surgery. We analyzed EZH2 expression and its activity as indicated by H3K27me3 levels comprising 373 patients with renal cell carcinoma in our institute. Outcome was assessed as overall survival and disease free survival using Kaplan-Meier analysis. Prognostic values of EZH2 and H3K27me3 expression for clinical outcomes were evaluated by Cox regression analysis. We used receiver operating characteristic to calculate diagnostic accuracy. High EZH2 expression correlates with poor overall survival in all patients, especially in advanced RCC, which is an independent prognostic factor in disease free survival and overall survival. Compared with EZH2, H3K27me3 expression is not an independent prognostic factor. The expressions of H3K27me3 and EZH2 are not completely consistent, which might be due to complicated interaction of Polycomb Repressor Complex 2. A combination of EZH2 expression and TNM stage could have better prognostic value than do TNM stage or EZH2 expression alone in both sets for disease free survival and overall survival. These results imply that evaluating intratumoral EZH2 density might improve prognostic value to the TNM staging system and inform treatment decisions for patients with late-stage renal cell carcinoma.
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DOI：
10.1073/pnas.0707292104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Hong, SunHwa;Cho, Young-Wook;Ge, Kai
通讯作者：
Ge, Kai
影响因子：
11.2
作者：
Liu, Haiou;Xu, Jiejie;Gu, Jianxin
通讯作者：
Gu, Jianxin
影响因子：
64.8
作者：
Varambally, S;Dhanasekaran, SM;Chinnaiyan, AM
通讯作者：
Chinnaiyan, AM
影响因子：
10.5
作者：
Mallen-St Clair, Jon;Soydaner-Azeloglu, Rengin;Bar-Sagi, Dafna
通讯作者：
Bar-Sagi, Dafna
影响因子：
64.8
作者：
Viré, E;Brenner, C;Fuks, F
通讯作者：
Fuks, F