Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury.
Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury.
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DOI：
10.3171/jns.1982.57.5.0667
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发表时间：
1982-11
影响因子：
4.1
通讯作者：
Wise Young;Eugene S. Flamm
中科院分区：
文献类型：
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作者：
Wise Young;Eugene S. Flamm
在猫脊髓严重挫伤（400 gm-cm）后45分钟给予高剂量甲基强的松龙（15至30 mg/kg），可迅速逆转脊髓损伤中发生的典型创伤后缺血。尽管静脉推注如此大剂量的皮质类固醇会引起全身性低血压，但白色血流改善。此外，这种治疗促进了挫伤脊髓中细胞外钙离子的恢复，并挽救了未治疗猫中丢失的诱发电位活动。这些数据表明，高剂量皮质类固醇治疗引起脊髓血管局部血管扩张。随后的血流量增加可能是高剂量皮质类固醇治疗对受损脊髓功能恢复和组织病理学表现的有益作用。
High-dose methylprednisolone (15 to 30 mg/kg), administered 45 minutes after severe contusion injury (400 gm-cm) to cat spinal cords, rapidly reverses the typical posttraumatic ischemia that occurs in spinal injuries. White matter blood flow improves despite the systemic hypotension associated with bolus intravenous injections of such massive corticosteroid doses. In addition, this treatment facilitates extracellular calcium ionic recovery in contused spinal cords, and salvages evoked potential activity that is lost in untreated cats. These data suggest that high-dose corticosteroid treatment causes local vasodilation of spinal cord blood vessels. The consequent blood flow increase may account for the beneficial effects of high-dose corticosteroid treatment on both functional recovery and histopathological appearance of injured spinal cords.