Signaling Pathways in Cell Polarity
Signaling Pathways in Cell Polarity
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DOI：
10.1101/cshperspect.a009654
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发表时间：
2012-06-01
影响因子：
7.2
通讯作者：
Macara, Ian G.
中科院分区：
文献类型：
--
作者：
McCaffrey, Luke Martin;Macara, Ian G.
在细胞极化过程中，信号转导的一个关键功能是在细胞皮质中创建具有不同脂肪和蛋白质组成并具有不同功能的空间隔离区域。极性可以自发地启动，也可以响应相邻细胞或可溶性因子的信号输入而启动，并通过正反馈回路稳定下来。在许多情况下，一组保守的蛋白质，PAR蛋白，在极性的建立和维持中起着核心作用。这些蛋白质通过主动地将彼此排除在质膜的特定区域而在细胞中产生和维持其独特的位置。PAR信号通路与许多其他控制细胞生长、死亡和组织的通路相交。
A key function of signal transduction during cell polarization is the creation of spatially segregated regions of the cell cortex that possess different lipid and protein compositions and have distinct functions. Polarity can be initiated spontaneously or in response to signaling inputs from adjacent cells or soluble factors and is stabilized by positive-feedback loops. A conserved group of proteins, the Par proteins, plays a central role in polarity establishment and maintenance in many contexts. These proteins generate and maintain their distinct locations in cells by actively excluding one another from specific regions of the plasma membrane. The Par signaling pathway intersects with multiple other pathways that control cell growth, death, and organization.