CAPRI: A Critical Assessment of PRedicted Interactions
CAPRI: A Critical Assessment of PRedicted Interactions
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DOI：
10.1002/prot.10381
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发表时间：
2003-07-01
影响因子：
2.9
通讯作者：
Wodak, SJ
中科院分区：
文献类型：
--
作者：
Janin, J;Henrick, K;Wodak, SJ
CAPRI是一项社区范围的实验，旨在评估蛋白质对接方法预测蛋白质-蛋白质相互作用的能力。19个小组参加了CAPRI的第1轮和第2轮，并根据已知的组成蛋白结构提交了7种蛋白质复合物的盲结构预测。这些预测与未发表的配合物的x射线结构进行了比较。我们在这里描述了启动CAPRI的动机，我们在选择目标和运行实验时应用的规则，以及一些已经可以得出的结论。结果强调需要新的评分功能和方法处理构象的变化，在一些目标系统中观察到的。CAPRI已经成为开发对接算法的计算生物学家社区的强大推动力。我们希望这一期的《蛋白质》也能引起结构生物学家的兴趣，我们呼吁他们为未来几轮CAPRI提供新的目标，以及所有认为蛋白质-蛋白质识别是一个基本过程的分子生物学家。(C) 2003 Wiley-Liss, Inc。
CAPRI is a communitywide experiment to assess the capacity of protein-docking methods to predict protein-protein interactions. Nineteen groups participated in rounds I and 2 of CAPRI and submitted blind structure predictions for seven protein-protein complexes based on the known structure of the component proteins. The predictions were compared to the unpublished X-ray structures of the complexes. We describe here the motivations for launching CAPRI, the rules that we applied to select targets and run the experiment, and some conclusions that can already be drawn. The results stress the need for new scoring functions and for methods handling the conformation changes that were observed in some of the target systems. CAPRI has already been a powerful drive for the community of computational biologists who development docking algorithms. We hope that this issue of Proteins will also be of interest to the community of structural biologists, which we call upon to provide new targets for future rounds of CAPRI, and to all molecular biologists who view protein-protein recognition as an essential process. (C) 2003 Wiley-Liss, Inc.