Demographic Inference Reveals African and European Admixture in the North American Drosophila melanogaster Population
Demographic Inference Reveals African and European Admixture in the North American Drosophila melanogaster Population
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DOI：
10.1534/genetics.112.145912
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发表时间：
2013-01-01
期刊：
影响因子：
3.3
通讯作者：
Laurent, Stefan
中科院分区：
文献类型：
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作者：
Duchen, Pablo;Zivkovic, Daniel;Laurent, Stefan
黑腹果蝇从撒哈拉以南的非洲传播到世界其他地方，在新的环境中定居。在这里，我们使用近似贝叶斯计算（ABC）方法对非洲（津巴布韦）、欧洲（荷兰）和北美（北卡罗来纳州）人口的联合人口统计进行了建模。通过测试不同的模型（包括持续迁移的场景），我们发现非洲和欧洲之间的混合最有可能产生北美人口，估计非洲血统的比例为15%。我们还重新审视了祖先人口（非洲）的人口统计，与之前的工作相反，我们发现瓶颈比扩张更适合津巴布韦的人口历史。最后，我们比较了在估计瓶颈模型下祖先种群的位点频谱与分析预测。
Drosophila melanogaster spread from sub-Saharan Africa to the rest of the world colonizing new environments. Here, we modeled the joint demography of African (Zimbabwe), European (The Netherlands), and North American (North Carolina) populations using an approximate Bayesian computation (ABC) approach. By testing different models (including scenarios with continuous migration), we found that admixture between Africa and Europe most likely generated the North American population, with an estimated proportion of African ancestry of 15%. We also revisited the demography of the ancestral population (Africa) and found-in contrast to previous work-that a bottleneck fits the history of the population of Zimbabwe better than expansion. Finally, we compared the site-frequency spectrum of the ancestral population to analytical predictions under the estimated bottleneck model.