SERUM LIPIDS IN INFECTION
SERUM LIPIDS IN INFECTION
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DOI：
10.1056/nejm196911132812001
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发表时间：
1969-01-01
影响因子：
158.5
通讯作者：
OLEARY, WM
中科院分区：
文献类型：
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作者：
GALLIN, JI;KAYE, D;OLEARY, WM
在革兰阴性杆菌感染患者中观察到血清总脂质浓度显著升高。这些患者的总脂质水平升高主要是由于血清甘油三酯或游离脂肪酸或两者的浓度显著增加。相反，革兰氏阳性球菌引起的严重感染患者的血清总脂质浓度正常。发烧但无感染者和流感患者的血清总脂质浓度正常，主要脂质类水平正常。感染性或血清性肝炎患者表现出中度高脂血症，这是由于血清甘油三酯和游离胆固醇浓度升高所致。脂蛋白电泳显示革兰阴性杆菌严重感染患者的高脂血症与前β脂蛋白水平升高有关。在肝炎患者中，前β-脂蛋白和β-脂蛋白水平升高。
Striking elevations in concentrations of total serum lipids were observed in patients with infection caused by gram-negative bacilli. The elevated levels of total lipid in these patients were due mainly to marked increases in serum concentrations of triglycerides or free fatty acids or both.In contrast, patients with severe infection caused by gram-positive cocci had normal concentrations of total serum lipids. Those with fever but no infection and those with influenza had normal concentrations of total serum lipids and normal levels of the major lipid classes. Patients with infectious or serum hepatitis demonstrated a moderate hyperlipidemia, which resulted from increased concentrations of serum triglycerides and free cholesterol. Lipoprotein electrophoresis demonstrated that the hyperlipidemia in patients with severe infection caused by gram-negative bacilli was related to increased levels of pre-beta-lipoproteins. In patients with hepatitis there were increased levels of pre-beta-lipoproteins and beta-lipoproteins.