The STOP-AB trial protocol: efficacy and safety of discontinuing patient antibiotic treatment when physicians no longer consider it necessary.
The STOP-AB trial protocol: efficacy and safety of discontinuing patient antibiotic treatment when physicians no longer consider it necessary.
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DOI：
10.1136/bmjopen-2016-015814
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发表时间：
2017-06-06
期刊：
影响因子：
2.9
通讯作者：
Robles, Purificacion
中科院分区：
文献类型：
--
作者：
Llor, Carl;Moragas, Ana;Robles, Purificacion
简介：自2011年以来，西班牙家庭医学协会建议全科医生（gp）在怀疑患者感染病毒时要求他们停止服用抗生素。然而，这种做法很少使用，因为对诊断的不确定性，对停止抗生素治疗的后果的恐惧，以及继续开抗生素处方的感知压力和与患者的潜在冲突是全科医生比抗生素耐药性更关心的问题。本研究的主要目的是确定当全科医生认为不再有必要停止抗生素治疗时，是否对出现严重症状的天数有任何影响。方法与分析：这是一项多中心、开放标签、随机对照临床试验。这项研究在西班牙的10个初级保健中心进行。我们纳入了18 - 75岁无并发症急性呼吸道感染（急性鼻窦炎、急性喉咙痛、流感或急性支气管炎）的患者，这些患者之前曾服用过任何剂量的抗生素
INTRODUCTION: Since 2011, the Spanish Society of Family Medicine has recommended general practitioners (GPs) to ask their patients to stop taking antibiotics when they suspect a viral infection. However, this practice is seldom used because uncertainty about diagnosis, and fear of consequences of discontinuing antibiotic therapy, as well as perceived pressure to continue prescribing antibiotics and potential conflict with patients are more of a concern for GPs than antibiotic resistance. The main objective of this study is to determine whether discontinuation of antibiotic therapy when a GP no longer considers it necessary has any impact on the number of days with severe symptoms.METHODS AND ANALYSIS: This is a multicentre, open-label, randomised controlled clinical trial. The study was conducted in 10 primary care centres in Spain. We included patients from 18 to 75 years of age with uncomplicated acute respiratory tract infections-acute rhinosinusitis, acute sore throat, influenza or acute bronchitis-who had previously taken any dose of antibiotic for