Overexpression of Amyloid Precursor Protein Promotes the Onset of Seborrhoeic Keratosis and is Related to Skin Ageing
Overexpression of Amyloid Precursor Protein Promotes the Onset of Seborrhoeic Keratosis and is Related to Skin Ageing
复制标题
淀粉样前体蛋白过度表达促进脂溢性角化病的发生并与皮肤衰老相关
DOI：
10.2340/00015555-2911
复制
发表时间：
2018-06-01
影响因子：
3.6
通讯作者：
Lu, Hongguang
中科院分区：
文献类型：
--
作者：
Li, Yuanying;Wang, Yu;Lu, Hongguang
脂溢性角化病是一种与年龄有关的皮肤病。淀粉样前体蛋白（APP）在老年性阿尔茨海默病的发病机制中起重要作用。本研究的目的是阐明APP在脂溢性角化病组织中的表达特征（n = 50），并探讨APP的产生是否与脂溢性角化病的发病和皮肤老化有关，包括正常皮肤中观察到的紫外线（UV）诱导的衰老（n = 79）。免疫组织化学、Western blotting和实时荧光定量PCR结果显示，APP及其下游产物（即淀粉样蛋白- β 42）在脂脂性角化病中的表达高于配对的邻近正常皮肤组织。相反，其关键分泌酶（即β -secretase1）的表达普遍较低。此外，APP在暴露于紫外线下的皮肤部位的表达高于未暴露于紫外线下的皮肤部位，并且在脂脂性角化病组织中，老年组（61-85岁）的表达高于年轻组（41-60岁）(p
Seborrhoeic keratosis is an age-related skin disease. Amyloid precursor protein (APP) plays an important role in the pathogenesis of age-related Alzheimer's disease. The aim of this study was to elucidate the expression characteristics of APP in seborrhoeic keratosis tissues (n = 50), and explore whether the production of APP is related to the onset of seborrhoeic keratosis and skin ageing, including ultraviolet (UV)-induced ageing, as observed in normal skin (n = 79). The results of immunohistochemistry, Western blotting and quantitative real-time PCR showed that APP and its downstream products (i.e. amyloid-beta 42) were more highly expressed in seborrhoeic keratosis than in paired adjacent normal skin tissues. In contrast, the expression of its key secretase (i.e. beta-secretase1) was generally low. Furthermore, APP expression was higher in UV-exposed than non-exposed skin sites, and expression in the older age group (61-85 years) was greater than that in the younger age group (41-60 years) in seborrhoeic keratosis tissues (p