European prospective investigation into cancer and nutrition (EPIC):: study populations and data collection
European prospective investigation into cancer and nutrition (EPIC):: study populations and data collection
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DOI：
10.1079/phn2002394
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发表时间：
2002-12-01
影响因子：
3.2
通讯作者：
Saracci, R
中科院分区：
文献类型：
--
作者：
Riboli, E;Hunt, KJ;Saracci, R
欧洲癌症和癌症前瞻性研究。营养(EPIC)是一项正在进行的多中心前瞻性队列研究，旨在调查营养与癌症之间的关系，以及研究其他疾病的可能性。这项研究目前有519978名参与者(366521名女性和153457名男性，年龄大多在35岁至70岁之间)，分布在10个欧洲国家的23个中心，对癌症发病率和特定原因死亡率进行了数十年的跟踪调查。在1992年至2000年期间在每个不同的中心进行登记时，通过关于生活方式变量的非饮食调查问卷和涉及日常饮食的饮食调查问卷收集了信息。进行了人体测量并采集了血液样本，从其中分离出血浆、血清、红细胞和黄褐色涂层部分，并将其等量长期储存，主要保存在液氮中。为了校准饮食测量，每个中心对参与者的分层随机样本实施了标准化的、计算机辅助的24小时饮食召回，总共有36 900名受试者。EPIC是当今世界上可用于癌症(和其他疾病)病因学前瞻性研究的最大单一资源，可整合关于生活方式和饮食的问卷数据、饮食和内源性新陈代谢(如激素和生长因子)的生物标记物以及遗传多态。首先，预计2003年初将公布嵌套在队列中的病例对照研究结果。本文件描述了史诗研究，目的是在今后报告在史诗队列中进行的实质性或方法性研究的文件中简化对它的提及。
The European Prospective Investigation into Cancer and. Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153457 men, mostly aged 35-70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrolment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case-control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.