CENTRAL SEROTONIN RECEPTORS AND DELAYED GASTRIC-EMPTYING IN NONULCER DYSPEPSIA
CENTRAL SEROTONIN RECEPTORS AND DELAYED GASTRIC-EMPTYING IN NONULCER DYSPEPSIA
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DOI：
10.1136/bmj.305.6848.280
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发表时间：
1992-08-01
影响因子：
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通讯作者：
DINAN, TG
中科院分区：
文献类型：
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作者：
CHUA, A;KEATING, J;DINAN, TG
目的：确定中枢5-羟色胺受体是否参与非溃疡性消化不良的病理生理学。设计：固相胃排空和催乳素对丁螺环酮激发反应的受试者间研究。受试者：12名符合非溃疡性消化不良标准的患者和12名年龄和性别匹配的对照。主要结果测量：固相胃排空的测定是通过对用锝-99m和铟-111标记的标准餐的运动进行放射性造影评估来进行的;通过口服丁螺环酮60 mg激发后催乳素释放测定中枢5-羟色胺1A受体的反应性。结果非溃疡性消化不良患者的固相胃排空显著延迟（患者t1/2=90.6（SD 14.5）分钟，对照组为54.6（10.7）分钟; 95%置信区间为24.7至46.7分钟，p
Objective-To determine whether central serotonin receptors are involved in the pathophysiology of non-ulcer dyspepsia.Design-Between subjects study of solid phase gastric emptying and prolactin response to buspirone challenge.Subjects-12 patients fulfilling criteria for non-ulcer dyspepsia and 12 age and sex matched controls.Main outcome measures-Solid phase gastric emptying measured by scintigraphic assessment of the movement of a standard meal labelled with technetium-99m and indium-111; responsiveness of central serotonin 1A receptors measured by the prolactin release following challenge with oral buspirone 60 mg.Results-Solid phase gastric emptying was significantly delayed in the patients with non-ulcer dyspepsia (t1/2=90.6 (SD 14.5) minutes in patients and 54.6 (10.7) minutes in controls; 95% confidence interval 24.7 to 46.7 minutes, p