Bone regeneration following the in vivo bioreactor principle: is in vitro manipulation of exogenous elements still needed?
Bone regeneration following the in vivo bioreactor principle: is in vitro manipulation of exogenous elements still needed?
复制标题
遵循体内生物反应器原理的骨再生：是否还需要体外操作外源元素？
DOI：
10.2217/rme-2016-0021
复制
发表时间：
2016-07-01
影响因子：
2.7
通讯作者：
Li, Qingfeng
中科院分区：
文献类型：
--
作者：
Huang, Ru-Lin;Liu, Kai;Li, Qingfeng
由于功能和美学重建的困难，大面积骨缺损的治疗是一个关键的挑战。骨组织工程是一种基于种子细胞、生长因子和生物支架体外操作的有前途的骨再生方法。然而，许多可怕的概念和技术挑战阻碍了实验成功的临床转化为临床实践。一种新兴的骨再生策略是利用身体作为生物反应器来培养传统的三联体，并利用身体自身的再生能力来创造新的骨组织。基于对骨再生和体内生物反应器原理的理解，我们假设，功能性骨组织最终可能仅使用自体肋骨膜在体内生成，而不需要任何外源性元素的参与。
Large bone defect treatment is a key challenge due to the difficulty of functional and aesthetic reconstruction. A promising approach for bone regeneration is bone tissue engineering which is based on in vitro manipulation of seed cells, growth factors and bioscaffolds. However, many formidable conceptual and technical challenges impede clinical translation of experimental successes into clinical practices. An emerging strategy for bone regeneration is using the body as a bioreactor to cultivate the traditional triad and leveraging the body's own regenerative capacity to create new bone tissue. Based on the understanding of bone regeneration and in vivo bioreactor principle, we hypothesize that functional bone tissue may be eventually generated in vivo only using autologous costal periosteum, without participation of any exogenous elements.