A Multi-regional Network Encoding Heading and Steering Maneuvers in Drosophila
A Multi-regional Network Encoding Heading and Steering Maneuvers in Drosophila
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DOI：
10.1016/j.neuron.2020.01.009
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发表时间：
2020-01
期刊：
影响因子：
16.2
通讯作者：
Hiroshi M. Shiozaki;Kazumi Ohta;H. Kazama
中科院分区：
文献类型：
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作者：
Hiroshi M. Shiozaki;Kazumi Ohta;H. Kazama
根据各种线索计算航向方向的内部感觉，包括动物的转向动作。虽然在多个大脑区域发现了编码航向和转向的神经元，但尚不清楚它们是否以及如何组织成神经回路。在这里，我们表明，在flyingDrosophila，标题和转向行为编码的特定类型的细胞连接的中央复合体（CX），涉及导航的大脑结构的子区域的人口动态。CX的扇形体（FB）中的柱状神经元表现出循环动力学，该动力学将有关转向行为和航向的信息复用。这些动态与椭圆体中的那些相协调，另一个CX子区域包含一个标题表示，尽管只有FB神经元翻转转向偏好取决于视觉环境。因此，导航系统跨越CX的多个子区域，其中特定的细胞类型显示协调但不同的上下文相关的动态。
An internal sense of heading direction is computed from various cues, including steering maneuvers of the animal. Although neurons encoding heading and steering have been found in multiple brain regions, it is unclear whether and how they are organized into neural circuits. Here we show that, in flyingDrosophila, heading and turning behaviors are encoded by population dynamics of specific cell types connecting the subregions of the central complex (CX), a brain structure implicated in navigation. Columnar neurons in the fan-shaped body (FB) of the CX exhibit circular dynamics that multiplex information about turning behavior and heading. These dynamics are coordinated with those in the ellipsoid body, another CX subregion containing a heading representation, although only FB neurons flip turn preference depending on the visual environment. Thus, the navigational system spans multiple subregions of the CX, where specific cell types show coordinated but distinct context-dependent dynamics.