STOCHASTIC DYNAMICS OF MICROTUBULES - A MODEL FOR CAPS AND CATASTROPHES
STOCHASTIC DYNAMICS OF MICROTUBULES - A MODEL FOR CAPS AND CATASTROPHES
复制标题
DOI：
10.1103/physrevlett.73.2372
复制
发表时间：
1994-10-24
影响因子：
8.6
通讯作者：
LEIBLER, S
中科院分区：
文献类型：
--
作者：
FLYVBJERG, H;HOLY, TE;LEIBLER, S
我们引入并解决了一个所谓的巨灾现象模型，即微管从生长状态到收缩状态的突然转变。该模型可以解释现有的实验结果，并解决一些长期存在的明显矛盾。特别是，该模型再现了观察到的灾难率和在突然稀释时灾难的等待时间。这也可以解释为什么最近的实验未能测量生长微管中的GTP含量，并提供了所谓的耦合水解机制。
We introduce and solve a phenomenological model for the so-called catastrophes, the abrupt transitions from the growing to the shrinking state of microtubules. The model may explain existing experimental results and resolve some long-standing apparent contradictions. In particular, the model reproduces observed catastrophe rates and waiting times for catastrophes upon sudden dilution. It may also explain why recent experiments fail to measure the GTP content in growing microtubules and provides a mechanism for so-called coupled hydrolysis.