Pharmaceutical otoprotection strategies to prevent impulse noise-induced hearing loss
Pharmaceutical otoprotection strategies to prevent impulse noise-induced hearing loss
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DOI：
10.1121/1.5132285
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发表时间：
2019-11-01
影响因子：
2.4
通讯作者：
DeBacker, J. Riley
中科院分区：
文献类型：
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作者：
Bielefeld, Eric C.;Harrison, Ryan T.;DeBacker, J. Riley
听力研究人员正在面临的挑战之一是成功地保护耳朵免受噪音伤害。几十年来，最有效的方法一直是基于改变噪声的声学特性，要么通过减少来自各种来源的噪声输出，通过环境控制干扰声暴露路径，要么通过个人听力保护装置改变个人的噪声剂量。由于一些声学修改程序的效率低下，药物耳保护的目标是使耳蜗不易受到伤害。短时间、高水平的脉冲噪声通常由小规模爆炸引起，与长期、低方差的噪声暴露相比，会对耳朵造成不同的伤害。因此，预期暴露在脉冲噪声中的耳朵可能需要不同的药物干预，无论是使用的化合物类型还是化合物给药的时间进程。目前的综述讨论了四种不同类别的化合物，它们已被测试为脉冲噪声耳鸣保护剂。在描述这些实验的过程中，特别强调了所使用的脉冲的声学特性，目的是为评估这些不同模型与人类脉冲噪声引起的听力损失的相关性提供背景。(C)2019年美国声学学会。
One of the ongoing challenges for hearing researchers is successful protection of the ear from noise injury. For decades, the most effective methods have been based on modifying the acoustic properties of the noise, either by reducing noise output from various sources, interfering in the acoustic exposure path with environmental controls, or altering the noise dose for the individual with personal hearing protection devices. Because of the inefficiencies of some of the acoustic modification procedures, pharmaceutical otoprotection is targeted at making the cochlea less susceptible to injury. Short-duration, high-level impulse noises, typically caused by small-scale explosions, cause different sets of injuries in the ear than long-duration, low-variance noise exposures. Therefore, the expectation is that the ears exposed to impulse noise may need different pharmaceutical interventions, both in type of compounds used and the time course of administration of the compounds. The current review discusses four different classes of compounds that have been tested as impulse noise otoprotectants. In the process of describing those experiments, particular emphasis is placed on the acoustic properties of the impulses used, with the goal of providing context for evaluating the relevance of these different models to human impulse noise-induced hearing loss. (C) 2019 Acoustical Society of America.