Xenopus bagpipe-related gene, koza, may play a role in regulation of cell proliferation.
Xenopus bagpipe-related gene, koza, may play a role in regulation of cell proliferation.
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爪蟾风笛相关基因 koza 可能在细胞增殖调节中发挥作用。
DOI：
10.1002/dvdy.10186
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Krieg,PaulA
中科院分区：
文献类型：
--
作者：
Newman,CraigS;Krieg,PaulA
The homeobox genekozais a new member of the vertebratebagpipe‐related gene family. Embryonic expression ofkozais observed at highest levels in the muscle layer of the somites and, during later development, is restricted to the lateral somitic cells, which correspond to slow twitch muscle tissue. Expression ofkozais also observed in the myocardial layer of the heart and in the cement gland. In each of these tissues,kozatranscription commences only after the expression of terminal differentiation markers. By injection of synthetic mRNA, we show that overexpression ofkozaleads to an apparent decrease in the number of cells in the somites. No reduction in cell number is observed whenkozais present in neural tissues, suggesting that koza exhibits some tissue specificity in regulation of cell proliferation. Embryonic manipulations show that restriction ofkozaexpression to the slow twitch muscle layer is independent of axial structures but is, at least partly, regulated by signals arising in ectodermal tissue. Finally, inDrosophila,bagpipeexpression is regulated by the hedgehog signaling pathway. By using ectopic expression, we show thatkozatranscription is positively regulated by banded hedgehog. This result indicates that regulation ofbagpipeexpression by hedgehog signaling is evolutionarily conserved. © 2002 Wiley‐Liss, Inc.
