The sigh and related behaviors.
The sigh and related behaviors.
复制标题
DOI：
10.1016/b978-0-323-91534-2.00015-1
复制
发表时间：
2022-01-01
影响因子：
--
通讯作者：
Severs, Liza J
中科院分区：
文献类型：
--
作者：
Ramirez, Jan-Marino;Vlemincx, Elke;Severs, Liza J
呼吸是一种关键、复杂且高度综合的行为。正常的有节奏的呼吸，也称为平静呼吸，散布着不同的呼吸相关行为。叹息就是此类行为之一，对于通过防止肺部肺泡逐渐塌陷（称为肺不张）来维持有效的气体交换至关重要。对于叹息和平静呼吸的产生至关重要的是延髓中被称为前博辛格复合体（preBotC）的区域。目前正在努力确定将叹息、打喷嚏、打哈欠和打嗝与其他大脑区域联系起来的细胞通路，以更好地了解它们如何在化学感觉、嗅觉和认知等其他行为的背景下进行整合和调节。解开这些相互作用可以为了解这些行为在唤醒、刺激警惕和某些行为状态的传递中的不同作用提供重要的见解。本章主要关注叹息的功能、它如何在 preBotC 中本地生成，以及叹息和认知调节之间潜在联系的功能含义。此外，我们还讨论了最近对控制打哈欠、打喷嚏和打嗝的途径和机制的见解。
Breathing is a critical, complex, and highly integrated behavior. Normal rhythmic breathing, also referred to as eupnea, is interspersed with different breathing related behaviors. Sighing is one of such behaviors, essential for maintaining effective gas exchange by preventing the gradual collapse of alveoli in the lungs, known as atelectasis. Critical for the generation of both sighing and eupneic breathing is a region of the medulla known as the preBotzinger Complex (preBotC). Efforts are underway to identify the cellular pathways that link sighing as well as sneezing, yawning, and hiccupping with other brain regions to better understand how they are integrated and regulated in the context of other behaviors including chemosensation, olfaction, and cognition. Unraveling these interactions may provide important insights into the diverse roles of these behaviors in the initiation of arousal, stimulation of vigilance, and the relay of certain behavioral states. This chapter focuses primarily on the function of the sigh, how it is locally generated within the preBotC, and what the functional implications are for a potential link between sighing and cognitive regulation. Furthermore, we discuss recent insights gained into the pathways and mechanisms that control yawning, sneezing, and hiccupping.