Cystatin C Associates with Arterial Stiffness in Older Adults
Cystatin C Associates with Arterial Stiffness in Older Adults
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DOI：
10.1681/asn.2008030318
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发表时间：
2009-05-01
影响因子：
13.6
通讯作者：
Sarnak, Mark J.
中科院分区：
文献类型：
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作者：
Madero, Magdalena;Wassel, Christina L.;Sarnak, Mark J.
大动脉通常在肾衰竭时变得僵硬，但很少有研究调查肾脏疾病早期阶段的动脉僵硬度。我们评估了老年人肾功能与主动脉脉搏波速度（aPWV）之间的相关性及其受种族、糖尿病或冠心病影响的可能性。我们在健康老化和身体组成（健康ABC）研究中测量了2468名参与者的aPWV;平均年龄为73.7岁，40%为黑人，24%患有糖尿病。根据胱抑素C水平将肾功能分为三组后，多变量分析显示，中、高胱抑素C组与5.3%的肾功能相关。（95%置信区间0.8 - 10.0%）和8.0%（95%置信区间2.2 - 14.1%）aPWV高于低胱抑素C组;然而，慢性肾脏疾病（根据估计的GFR定义）
Large arteries commonly become stiff in kidney failure, but few studies have investigated arterial stiffness in earlier stages of kidney disease. We evaluated the association between kidney function and aortic pulse wave velocity (aPWV) and its potential modification by race, diabetes, or coronary heart disease in older adults. We measured aPWV in 2468 participants in the Health Aging and Body Composition (Health ABC) study; mean age was 73.7 yr, 40% were black, and 24% had diabetes. After categorizing kidney function into three groups on the basis of cystatin C level, multivariable analysis revealed that the medium and high cystatin C groups associated with a 5.3% (95% confidence interval 0.8 to 10.0%) and 8.0% (95% confidence interval 2.2 to 14.1%) higher aPWV than the low cystatin C group; however, chronic kidney disease, as defined by estimated GFR