Postoperative adjuvant chemotherapy combined with intracavitary brachytherapy in early-stage cervical cancer patients with intermediate risk factors
Postoperative adjuvant chemotherapy combined with intracavitary brachytherapy in early-stage cervical cancer patients with intermediate risk factors
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DOI：
10.2147/ott.s107146
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发表时间：
2016-01-01
影响因子：
4
通讯作者：
Sheng, Xiugui
中科院分区：
文献类型：
--
作者：
Yu, Hao;Zhang, Linlin;Sheng, Xiugui
目的：方法：选取2010年2月至2014年3月在山东省肿瘤医院和山东省肿瘤研究所治疗的中危早期宫颈鳞癌患者133例，分析术后辅助治疗对患者生存的影响。所有患者均接受辅助治疗，并分为三组：盆腔放疗（RT; N=42），辅助化疗+腔内放疗（CT+ICRT; N=47），或同步放化疗（CCRT; N=44）。结果：RT、CT+ICRT和CCRT的3年无病生存率分别为94.0%、93.4%和97.6%，差异无显著性（P>0.05）。CCRT组Ⅲ-Ⅳ级急性毒性反应发生率（34.1%）高于RT组（9.5%）或CT+ICRT组（16.7%; P
Objective: To investigate the impact of postoperative adjuvant therapy on survival of patients with intermediate risk early-stage cervical squamous cell carcinoma.Methods: A total of 133 consecutive patients with intermediate risk early-stage cervical squamous cell carcinoma treated at Shandong Cancer Hospital and Institute from February 2010 to March 2014 were enrolled in our study. All patients received adjuvant therapy and were subdivided into three groups: pelvic radiotherapy (RT; N=42), adjuvant chemotherapy + intracavitary radiotherapy (CT+ICRT; N=47), or concurrent chemoradiation (CCRT; N=44). Disease-free survival (DFS) and therapeutic complications were evaluated.Results: There were no significant differences in DFS for patients treated with RT, CT+ICRT, and CCRT (P>0.05) with 3-year rates of 94.0%, 93.4%, and 97.6%, respectively. Frequencies of grade III-IV acute toxicities were higher in patients treated with CCRT (34.1%) than those treated with RT (9.5%) or CT+ICRT (16.7%; P