The effect of bioactive glass content on synthesis and bioactivity of composite poly (lactic-co-glycolic acid)/bioactive glass substrate for tissue engineering
The effect of bioactive glass content on synthesis and bioactivity of composite poly (lactic-co-glycolic acid)/bioactive glass substrate for tissue engineering
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DOI：
10.1016/j.biomaterials.2004.06.027
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发表时间：
2005-05-01
期刊：
影响因子：
14
通讯作者：
Ducheyne, P
中科院分区：
文献类型：
--
作者：
Yao, J;Radin, S;Ducheyne, P
组织工程学为骨组织移植提供了一条新的途径。在这方面受到关注的一种材料是聚合物聚（乳酸-共-乙醇酸）（PLGA）。它具有生物吸收可控和易于加工的优点。另一种感兴趣的材料是生物活性玻璃（BG），其显示出刺激骨祖细胞的成骨细胞分化的能力。在这项研究中。我们报道了PLGA/BG复合材料的最佳合成参数和表面磷酸钙（Ca-P）相形成的动力学。使用扫描电子显微镜/能量色散X射线分析（SEM/EDXA）确认磷酸钙层的形成。以PLGA-30%BG微球为载体构建骨组织工程多孔支架，观察其对骨髓基质细胞（MSC）成骨的促进作用。这种多孔支架支持MSC增殖并促进MSC分化为表达成骨细胞表型的细胞。因此，它作为骨替代材料具有巨大的潜力。(C)2004爱思唯尔有限公司保留所有权利。
Tissue engineering offers a promising new approach to bone tissue grafting. One material that has received attention in this regard is the polymer poly (lactic-co-glycolic acid) (PLGA). It has the advantage of controllable bioresorption and ease of processing. Another material of interest is bioactive glass (BG), which show, the ability to stimulate osteoblast differentiation of osteoprogenitor cells. In this study.. we reported on the optimal synthesis parameters and the kinetics of formation of calcium phosphate (Ca-P) phase at the surface of PLGA/BG composites. The formation of calcium phosphate layer was confirmed using scanning electron microscopy/energy dispersive X-ray analysis (SEM/EDXA). PLGA-30%BG microspheres based porous scaffolds for bone tissue engineering were examined for their ability to promote osteogenesis of marrow stromal cells (MSC). This porous scaffold supported both MSC proliferation and promoted MSC differentiation into cells expressing the osteoblast phenotype. It therefore demonstrates significant potential as a bone replacement material. (C) 2004 Elsevier Ltd. All rights reserved.