GAzer: gene set analyzer
GAzer: gene set analyzer
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DOI：
10.1093/bioinformatics/btm144
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发表时间：
2007-07-01
期刊：
影响因子：
5.8
通讯作者：
Chu, In-Sun
中科院分区：
文献类型：
--
作者：
Kim, Sang-Bae;Yang, Sungjin;Chu, In-Sun
基因集分析器（GAzer）是一种基于网络的集成基因集分析工具，涵盖先前报道的参数和非参数模型。基于对所报告算法的模拟测试，我们分类并实现了三种主要统计方法，包括人类、小鼠、大鼠和酵母等十个基因集类别的 z 统计、基因排列和样本排列。该工具可识别通过 z 统计量和 z 检验或排列检验的 P 值评分的显着改变的基因集，并提供 q 值和 Bonferroni P 值来纠正多重假设检验。 GAzer 允许用户观察基因集中每个基因表达的变化，或者查看包含感兴趣基因的基因集的重要性，从而允许在基因和基因集水平上进行交互式数据分析。此外，GAzer 还为每个基因提供了广泛的注释。
Gene Set Analyzer (GAzer) is a web-based integrated gene set analysis tool covering previously reported parametric and non-parametric models. Based on a simulation test for the reported algorithms, we classified and implemented three main statistical methods consisting of the z-statistic, gene permutation and sample permutation for ten gene set categories including Gene Ontology (GO) for human, mouse, rat and yeast. This tool identifies significantly altered gene sets scored by z-statistics and P-values from the z-test or permutation test and provides q-values and Bonferroni P-values to correct multiple hypothesis testing. GAzer allows users to observe changes in expression of each gene in a gene set or to see the significance of the gene sets containing a gene(s) of interest, thus allowing interactive data analysis both at the gene and gene set level. Moreover, GAzer offers extensive annotation for each gene.