Heritability of White Matter Fiber Tract Shapes: A HARDI Study of 198 Twins.
Heritability of White Matter Fiber Tract Shapes: A HARDI Study of 198 Twins.
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DOI：
10.1007/978-3-642-24446-9_5
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Thompson, Paul M
中科院分区：
文献类型：
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作者：
Jin, Yan;Shi, Yonggang;Joshi, Shantanu H;Jahanshad, Neda;Zhan, Liang;de Zubicaray, Greig I;McMahon, Katie L;Martin, Nicholas G;Wright, Margaret J;Toga, Arthur W;Thompson, Paul M
扩散张量图像的遗传分析在揭示影响大脑完整性和连通性的特定遗传变异方面显示出巨大的希望。大多数DTI的遗传研究分析了图像空间（如分数各向异性的3D地图）中基于体素的扩散指数，而忽略了通道几何。在这里，我们提出了一种自动化的工作流程，使用白质概率图谱来聚类纤维，并对纤维束的形状特征进行遗传分析。我们将我们的方法应用于198对健康的年轻成年双胞胎（年龄：20-30岁）的4-特斯拉高角分辨率扩散成像（HARDI）数据的大型研究。说明性结果显示了几个主要区域形状的遗传性，如彩色编码地图。
Genetic analysis of diffusion tensor images (DTI) shows great promise in revealing specific genetic variants that affect brain integrity and connectivity. Most genetic studies of DTI analyze voxel-based diffusivity indices in the image space (such as 3D maps of fractional anisotropy) and overlook tract geometry. Here we propose an automated workflow to cluster fibers using a white matter probabilistic atlas and perform genetic analysis on the shape characteristics of fiber tracts. We apply our approach to large study of 4-Tesla high angular resolution diffusion imaging (HARDI) data from 198 healthy, young adult twins (age: 20–30). Illustrative results show heritability for the shapes of several major tracts, as color-coded maps.