Incidence and risk factors for human papillomavirus infections in young female online daters.
Incidence and risk factors for human papillomavirus infections in young female online daters.
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年轻女性在线约会者人乳头瘤病毒感染的发病率和危险因素。
DOI：
10.1002/jmv.24891
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发表时间：
2017
影响因子：
12.7
通讯作者：
Winer,RachelL
中科院分区：
文献类型：
--
作者：
Ma,Sharon;Stern,JoshuaE;Feng,Qinghua;Hughes,JamesP;Hawes,StephenE;Winer,RachelL
在使用互联网约会网站的年轻女性中，人乳头瘤病毒（HPV）感染的风险因素尚不明确。从2010年到2012年，我们跟踪了18至24岁的女性互联网约会者（N= 164），每三年一次，平均为期1年。女性收集并返回自己收集的阴道样本进行HPV基因分型和健康和行为问卷调查。我们使用Kaplan-Meier方法估计临床相关HPV感染（高危HPV、HPV-6或HPV-11）的发生率，并使用广义估计方程和Firth logistic回归确定相关风险因素。在登记时，女性报告了6名男性性伴侣的中位寿命，36%的人报告了HPV疫苗接种史。临床相关HPV的12个月累积发生率为32.9%（95%CI：26.0 - 41.0%）。报告最近通过互联网认识的男性性伴侣与没有通过互联网认识的男性性伴侣与HPV事件无显著相关性（比值比[OR] = 0.91，95%CI：0.53 - 1.55）。在调整终生伴侣数量的多变量分析中，在过去6个月内报告新的和/或多个伴侣与HPV事件呈正相关（OR = 6.38，95%CI：1.56 - 26.02，与报告最近没有伴侣相比）。在一个单独的模型中，自我报告≥1剂HPV疫苗与疫苗型HPV呈负相关（6/11/16/18）（OR = 0.21，95%CI：0.05 - 0.86），但在调整性史后，这种相关性减弱，无统计学意义（OR = 0.36，95%CI：0.09 - 1.43）。虽然最近的高风险性行为与HPV事件有关，但与通过互联网认识的伴侣发生性关系与年轻女性互联网约会者的HPV风险增加无关。虽然在调整性史后没有统计学意义，但HPV疫苗接种显示出对疫苗型HPV感染的实质性保护。
Risk factors for incident human papillomavirus (HPV) infections are undefined in young women who use internet dating Web sites. From 2010‐2012 we followed 18‐ to 24‐year‐old female internet daters (N= 164) triannually for a mean of 1 year. Women collected and returned self‐collected vaginal samples for HPV genotyping and health and behavior questionnaires. We used Kaplan‐Meier methods to estimate incidence of clinically relevant HPV infection (high‐risk HPV, HPV‐6, or HPV‐11) and generalized estimating equations and Firth logistic regression to identify associated risk factors. At enrollment, women reported a median lifetime number of six male sex partners, and 36% reported a history of HPV vaccination. The 12‐month cumulative incidence of clinically relevant HPV was 32.9% (95%CI: 26.0‐41.0%). Reporting a recent male sex partner met via the internet versus not was not significantly associated with incident HPV (odds ratio [OR] = 0.91, 95%CI: 0.53‐1.55). In multivariate analysis adjusted for lifetime number of partners, reporting new and/or multiple partners in the past 6 months was positively associated with incident HPV (OR = 6.38, 95%CI: 1.56‐26.02, compared to reporting no recent partners). In a separate model, self‐reporting ≥1 dose of HPV vaccine was inversely associated with vaccine‐type HPV (6/11/16/18) (OR = 0.21, 95%CI: 0.05‐0.86), but the association was attenuated and not statistically significant after adjusting for sexual history (OR = 0.36, 95%CI: 0.09‐1.43). While recent high‐risk sexual behavior was associated with incident HPV, sex with partners met via the internet was not associated with increased HPV risk in young female internet daters. Although not statistically significant after adjusting for sexual history, HPV vaccination showed substantial protection against vaccine‐type HPV infection.