Choroidal morphologic features in central serous chorioretinopathy using ultra-widefield optical coherence tomography
Choroidal morphologic features in central serous chorioretinopathy using ultra-widefield optical coherence tomography
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DOI：
10.1007/s00417-022-05905-1
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发表时间：
2022-11-19
影响因子：
2.7
通讯作者：
Sakamoto, Taiji
中科院分区：
文献类型：
--
作者：
Funatsu, Ryoh;Sonoda, Shozo;Sakamoto, Taiji
目的应用超宽视场光学相干断层扫描（OCT）分析中枢性浆液性脉络膜视网膜病变（CSC）的脉络膜形态学变化。方法采用单中心病例对照研究，纳入65只CSC眼（男性52只，年龄55.6 +/- 13.0岁）和65只健康眼（男性50只，年龄57.1 +/- 17.9岁）。使用UWF-OCT（视角，200度）进行实形校正，创建自动脉络膜厚度（CT）图。CT图分为中心（0-30度）、中间（30-60度）和外围（60-100度）3个子区域，由垂直线和水平线划分。在调整了受试者的人口学和临床因素后，研究了CSC组和对照组之间从中央到外周区域的CT和CT变化率（CTCR）的差异。此外，我们评估了黄斑漩涡静脉扩张模式（VVDP），并检查了CSC患者和对照组之间每种漩涡静脉扩张模式的CT和CTCR差异。结果CSC患者在所有部位的CT均高于对照组（CSC与对照组相比，周围区域：颞上284.4 +/- 71.2 μ m vs. 220.4 +/- 71.2 μ m，颞下263.3 +/- 69.2 μ m vs. 195.3 +/- 52.3 μ m，鼻上251.9 +/- 70.3 μ m vs. 189.5 +/- 58.1 μ m，鼻下193.6 +/- 71.2 μ m vs. 146.3 +/- 48.9 μ m，所有部位P < 0.0001）。只有上显性型VVDP， CSC眼的CTCR明显大于对照组（CSC患者vs.对照组，颞上32.1 +/- 9.9% vs. 4.6 +/- 23.1%，颞下44.0 +/- 11.2% vs. 25.6 +/- 16.8%，鼻上42.6 +/- 9.8% vs. 22.2 +/- 19.4%，鼻下57.6 +/- 41.2% vs. 41.2 +/- 13.9%，所有区域P < 0.0001）。结论CSC的黄斑脉络膜增厚，甚至在周围区域也有，而上显性型的黄斑脉络膜增厚更为严重。VVDP可能会影响过量流体的位置。
Purpose To analyze the choroidal morphological changes in central serous chorioretinopathy (CSC) using ultra-widefield (UWF)-optical coherence tomography (OCT).Methods This single-center, case-control study included 65 CSC eyes (52 males; age, 55.6 +/- 13.0 years) and 65 healthy eyes (50 males; age, 57.1 +/- 17.9 years). UWF-OCT (viewing angle, 200 degrees) with real-shape correction was used to create an automated choroidal thickness (CT) map. The CT map had three sub-areas: the central (0-30 degrees), middle (30-60 degrees), and peripheral areas (60-100 degrees), and was divided by vertical and horizontal lines. Differences in the CT and the CT change rate (CTCR) from the central to peripheral areas were examined between the CSC and control groups after adjusting for subjects' demographic and clinical factors. Furthermore, we assessed the vortex veins dilation patterns (VVDP) in the macula and examined the CT and the CTCR differences between CSC patients and controls for each VVDP.Results CSC patients had greater CT than those of the controls in all sectors (CSC vs. controls, the peripheral area: supratemporal 284.4 +/- 71.2 mu m vs. 220.4 +/- 71.2 mu m, infratemporal 263.3 +/- 69.2 mu m vs. 195.3 +/- 52.3 mu m, supranasal 251.9 +/- 70.3 mu m vs. 189.5 +/- 58.1 mu m, infranasal 193.6 +/- 71.2 mu m vs. 146.3 +/- 48.9 mu m, P < 0.0001 for all sectors). The CTCR was apparently larger in CSC eyes than controls only for the upper-dominant type of VVDP (CSC patients vs. controls, supratemporal 32.1 +/- 9.9% vs. 4.6 +/- 23.1%, infratemporal 44.0 +/- 11.2% vs. 25.6 +/- 16.8%, supranasal 42.6 +/- 9.8% vs. 22.2 +/- 19.4%, infranasal 57.6 +/- 41.2% vs. 41.2 +/- 13.9%, P < 0.0001 for all sectors).Conclusions CSC has a thicker choroid, even in the peripheral areas, and the macular choroidal thickening was more severe in the upper-dominant type of VVDP. VVDP may affect the location of excessive fluid.