Studies on delayed neurotoxicity produced by some organophosphorus compounds.
Studies on delayed neurotoxicity produced by some organophosphorus compounds.
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DOI：
10.1111/j.1749-6632.1969.tb15851.x
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发表时间：
1969-01-01
影响因子：
5.2
通讯作者：
Johnson, M K
中科院分区：
文献类型：
--
作者：
Aldridge, W N;Barnes, J M;Johnson, M K
最好的试验动物是母鸡，大部分的病理研究都是在母鸡身上进行的。虽然不同化合物的病变分布可能有所不同（Cavanagh et al., 1961），但病变似乎是一个“死亡”过程，神经细胞远端的神经末梢受到影响，病变局限于长束（Cavanagh, 1964）。因此，没有理由认为不同有机磷化合物处理后导致病变的基本生化机制是不同的。不同物种施用同一种化合物后的病理变化研究较少。
The best test animal is the hen, and most of the pathology has been carried out on this species. Although the distribution of the lesion may vary somewhat from compound to compound (Cavanagh et al., 1961) the lesion appears to be a “dying-back” process, the ends of the nerves distal to the nerve cell being affected and the lesion being confined to the long tracts (Cavanagh, 1964). There is thus no reason to believe that the basic biochemical mechanism leading to the lesion is different after treatment with different organophosphorus compounds. The pathology in different species after administration of the same compound has been less studied.