Regulation of glycolysis and pentose-phosphate pathway by nitric oxide:: Impact on neuronal survival
Regulation of glycolysis and pentose-phosphate pathway by nitric oxide:: Impact on neuronal survival
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DOI：
10.1016/j.bbabio.2008.04.011
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发表时间：
2008-07-01
影响因子：
4.3
通讯作者：
Almeida, Angeles
中科院分区：
文献类型：
--
作者：
Bolanos, Juan P.;Delgado-Esteban, Maria;Almeida, Angeles
除了通过环GMP调节神经功能的重要作用外，一氧化氮正在成为大脑能量保存的内源性生理调节剂。因此，一氧化氮抑制神经元和胶质细胞中的细胞色素c氧化酶活性，导致线粒体能量产生的下调。随后AMP的增加促进了5'-AMP依赖性蛋白激酶的激活，从而迅速触发糖酵解途径的主要调节因子- 6-磷酸果糖-l-激酶和大脑中主要葡萄糖转运蛋白Glut1和GIut3的激活。此外，一氧化氮激活葡萄糖-6-磷酸脱氢酶，这是戊糖-磷酸途径的第一步和限速步骤。在这里，我们回顾了最近的证据表明，一氧化氮通过调节糖酵解和戊糖-磷酸途径之间葡萄糖-6-磷酸消耗的平衡，对神经元能量代谢施加了良好的控制。这可能对我们理解氧化应激和生物能量危机中控制神经元存活的机制具有重要意义。(c) 2008 Elsevier B.V.版权所有
Besides its essential role at regulating neural functions through cyclic GMP, nitric oxide is emerging as an endogenous physiological modulator of energy conservation for the brain. Thus, nitric oxide inhibits cytochrome c oxidase activity in neurones and glia, resulting in down-regulation of mitochondrial energy production. The subsequent increase in AMP facilitates the activation of 5'-AMP-dependent protein kinase, which rapidly triggers the activation of 6-phosphofructo-l-kinase - the master regulator of the glycolytic pathway - and Glut1 and GIut3 - the main glucose transporters in the brain. In addition, nitric oxide activates glucose-6-phosp hate dehydrogenase, the first and rate-limiting step of the pentose-phosphate pathway. Here, we review recent evidences suggesting that nitric oxide exerts a fine control of neuronal energy metabolism by tuning the balance of glucose-6-phosphate consumption between glycolysis and pentose-phosphate pathway. This may have important implications for our understanding of the mechanisms controlling neuronal survival during oxidative stress and bioenergetic crisis. (c) 2008 Elsevier B.V. All rights reserved.