Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity
Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity
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DOI：
10.1093/ajcn/87.3.567
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发表时间：
2008-03-01
影响因子：
7.1
通讯作者：
Clifton, Peter M.
中科院分区：
文献类型：
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作者：
Keogh, Jennifer B.;Brinkworth, Grant D.;Clifton, Peter M.
背景：超低碳水化合物、高饱和脂肪减肥饮食（LC）对肱动脉血流介导扩张（FMD）和内皮功能标志物的影响尚不清楚。目的：比较LC与等热量高碳水化合物、低饱和脂肪饮食（HC）对内皮功能和心血管疾病（CVD）风险标志物的影响。设计：在减肥8周前后测量FMD、内皮功能标志物（n = 70）和CVD风险。99名年龄为50.0 +/- 8.3岁，体重指数（kg/m(2)）为33.7 +/- 4.1的受试者完成了研究。结果：两种饮食的平均（+/- SD） FMD无显著变化（P = 0.55）。两种饲粮均提高了猪的脉搏波速度（P < 0.01）。内皮标志物、E-和P选择素、细胞内和细胞粘附分子-1、组织型纤溶酶原激活剂和纤溶酶原激活剂抑制剂-1降低（P < 0.001），饮食无影响。脂联素无明显变化。与HC相比，LC组减少的体重更多（饲粮x时间相互作用P = 0.05），腹部脂肪量更多（饲粮x时间相互作用P = 0.05）。低密度脂蛋白胆固醇与HC的交互作用比LC的交互作用更明显（P < 0.05，时间x）， c反应蛋白与HC的交互作用比LC的交互作用更明显（P < 0.05，时间x）。同型半胱氨酸随LC的增加而增加（饲粮x时间互作P < 0.01）。叶酸含量随LC的增加而降低，随HC的增加而增加（P < 0.05，饲粮x时间交互作用P < 0.001）。结论：LC对口蹄疫无损害。我们观察到两种饮食对大多数CVD危险因素的有益影响。该试验已在澳大利亚临床试验注册中心注册为ACTR NO 12606000203550。
Background: The effects of a very-low-carbohydrate, highsaturated-fat weight-loss diet (LC) on brachial artery flow-mediated dilatation (FMD) and markers of endothelial function are unknown.Objective: The effect of an LC on markers of endothelial function and cardiovascular disease (CVD) risk was compared with that of an isocaloric high-carbohydrate, low-saturated-fat diet (HC).Design: FMD and markers of endothelial function (n = 70) and CVD risk were measured before and after 8 wk of weight loss. Ninety-nine subjects aged 50.0 +/- 8.3 y with a body mass index (in kg/m(2)) of 33.7 +/- 4.1 completed the study.Results: Mean (+/- SD) FMD did not change significantly (P = 0.55) with either diet. Pulse wave velocity improved with both diets (P < 0.01). Endothelial markers, E- and P selectin, intracellular and cellular-adhesion molecule-1, tissue-type plasminogen activator, and plasminogen activator inhibitor-1 decreased (P < 0.001), with no diet effect. Adiponectin did not change significantly. More weight (P = 0.05 for diet x time interaction) and more abdominal fat mass (P = 0.05 for diet x time interaction) were lost with the LC than with the HC. LDL cholesterol decreased more with the HC than with the LC (P < 0.05, time x diet), and C-reactive protein decreased more with the HC than with the LC (P < 0.05 for diet x time interaction). Homocysteine increased more with the LC (P < 0.01 for diet x time interaction). Folate decreased with the LC and increased with the HC (P < 0.05, time; P < 0.001 for diet x time interaction).Conclusion: An LC does not impair FMD. We observed beneficial effects of both diets on most of the CVD risk factors measured. This trial was registered with the Australian Clinical Trials Registry as ACTR NO 12606000203550.