Graft-versus-myeloma effect: Proof of principle
Graft-versus-myeloma effect: Proof of principle
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DOI：
10.1182/blood.v87.3.1196.bloodjournal8731196
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发表时间：
1996-02-01
期刊：
影响因子：
20.3
通讯作者：
Barlogie, B
中科院分区：
文献类型：
--
作者：
Tricot, G;Vesole, DH;Barlogie, B
移植物抗肿瘤效应在白血病中已经得到了很好的证实，但在多发性骨髓瘤中还没有。一位40岁的骨髓瘤患者，对标准化疗和自体移植无效，在接受分次全身照射、硫代替巴和环磷酰胺的预适应后，接受了匹配的无关T细胞耗竭移植。这一过程导致移植后2.5个月内出现一过性和不完全反应，并有迅速进展的疾病的证据。然后，患者接受了少量供者外周血单核细胞(CD3细胞1.2x10(6)/kg)，而不进行任何进一步的细胞毒治疗。病情完全缓解，至今已持续14个多月。这一过程与严重、急性和随后有限的慢性移植物抗宿主病(GVHD)有关。这份报告提供了异基因移植后移植物抗骨髓瘤效应的第一个直接证据。(C)1996年由美国血液病学会主办。
The presence of a graft-versus-tumor effect has been well established in leukemia but not in multiple myeloma. A 40-year-old patient with myeloma refractory to standard chemotherapy and autologous transplantation received matched unrelated T-cell-depleted transplant after conditioning with fractionated total-body irradiation, thiotepa, and cyclophosphamide. This procedure resulted in a transient and incomplete response with evidence of rapidly progressive disease within 2.5 months posttransplantation. The patient then received a small number of donor peripheral blood (PB) mononuclear cells (CD3 cells 1.2 x 10(6)/kg) without any further cytotoxic therapy. A complete remission was attained, lasting now for more than 14 months. The procedure was associated with severe acute and subsequently limited chronic graft-versus-host disease (GVHD). This report provides the first direct evidence of a graft-versus-myeloma effect after allogeneic transplantation. (C) 1996 by The American Society of Hematology.