Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome
Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome
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DOI：
10.1093/infdis/jiy466
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发表时间：
2019-01-01
影响因子：
6.4
通讯作者：
Chang, Aileen Y.
中科院分区：
文献类型：
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作者：
Lynch, Rebecca M.;Mantus, Grace;Chang, Aileen Y.
中和抗体在寨卡诱发的格林-巴利综合征 (GBS) 中的作用尚未得到研究。我们使用 2016 年哥伦比亚寨卡疫情的血清进行了一项病例对照研究，以确定针对寨卡病毒 (ZIKV) 和登革热病毒血清型 2 (DENV2) 的中和抗体活性。我们观察到，与未感染对照者相比，ZIKV 感染者中针对 DENV2 的中和抗体滴度有所增加，并且与非 GBS ZIKV 感染对照者相比，诊断为 GBS 的 ZIKV 感染者中的 ZIKV 和 DENV2 滴度更高。这些数据表明，针对 DENV 和 ZIKV 的高中和抗体滴度与 ZIKV 感染期间的 GBS 相关。
The role of neutralizing antibodies in Zika-induced Guillain-Barre syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.