Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-κB signalling
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-κB signalling
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DOI：
10.1136/gut.2008.169052
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发表时间：
2009-08-01
期刊：
影响因子：
24.5
通讯作者：
Wijmenga, C.
中科院分区：
文献类型：
--
作者：
Trynka, G.;Zhernakova, A.;Wijmenga, C.
目的：我们先前的腹腔疾病全基因组关联研究（GWAS）涉及人类白细胞抗原（HLA）区域和8个新风险区域的风险变体。为了确定更多的腹腔疾病位点，我们选择了458个单核苷酸多态性（SNPs），表现出更温和的关联，在GWAS基因分型和分析在四个独立的cohols.Design：458 SNPs进行了测定，在1682例和3258控制从三个人群（英国，爱尔兰和荷兰）。我们将结果与最初的GWAS队列（767例英国病例和1422例对照）相结合; 6个SNP与p53相关。
Objective: Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed more modest association in the GWAS for genotyping and analysis in four independent cohorts.Design: 458 SNPs were assayed in 1682 cases and 3258 controls from three populations (UK, Irish and Dutch). We combined the results with the original GWAS cohort (767 UK cases and 1422 controls); six SNPs showed association with p