Dopaminergic stimulation facilitates working memory and differentially affects prefrontal low theta oscillations
Dopaminergic stimulation facilitates working memory and differentially affects prefrontal low theta oscillations
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DOI：
10.1016/j.neuroimage.2014.03.011
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发表时间：
2014-07-01
期刊：
影响因子：
5.7
通讯作者：
Bunzeck, Nico
中科院分区：
文献类型：
--
作者：
Eckart, Cindy;Fuentemilla, Lluis;Bunzeck, Nico
我们使用脑电图（EEG）和精神药理学刺激来研究多巴胺在工作记忆（WM）期间神经振荡中的作用。根据受试者内部设计，健康人在执行 Sternberg WM 范例之前接受多巴胺前体左旋多巴（150 毫克）或安慰剂。在这里，必须在三种不同的负载条件（两个、四个或六个项目）下延迟 5 秒存储样本图像序列。第二天，测试了图像的长期记忆（LTM）。在行为上，左旋多巴改善了 WM 和 LTM 性能，作为 WM 负荷的函数。更准确地说，在四负载条件下存在特定的药物效应，在 WM 任务中对探针的反应时间更快，在 LTM 任务中校正命中率更高。在维护期间，WM 负载对正面传感器的高θ (5-8 Hz) 和α (9-14 Hz) 频率范围内的功率存在线性和二次影响。重要的是，通过负载相互作用（模仿行为结果）的药物仅在低θ功率（2-4 Hz）下被发现。因此，我们的结果表明前额叶低θ振荡、WM期间的多巴胺能神经调节和随后的LTM表现之间存在特定联系。 (C) 2014 Elsevier Inc. 保留所有权利。
We used electroencephalography (EEG) together with psychopharmacological stimulation to investigate the role of dopamine in neural oscillations during working,memory (WM). Following a within-subjects design, healthy humans either received the dopamine precursor L-Dopa (150 mg) or a placebo before they performed a Sternberg WM paradigm. Here, sequences of sample images had to be memorized for a delay of 5 s in three different load conditions (two, four or six items). On the next day, long-term memory (LTM) for the images was tested. Behaviorally, L-Dopa improved WM and LTM performance as a function of WM load. More precisely, there was a specific drug effect in the four-load condition with faster reaction times to the probe in the WM task and higher corrected hit-rates in the LTM task. During the maintenance period, there was a linear and quadratic effect of WM load on power in the high theta (5-8 Hz) and alpha (9-14 Hz) frequency range at frontal sensors. Importantly, a drug by load interaction - mimicking the behavioral results - was found only in low theta power (2-4 Hz). As such, our results indicate a specific link between prefrontal low theta oscillations, dopaminergic neuromodulation during WM and subsequent LTM performance. (C) 2014 Elsevier Inc. All rights reserved.