Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome
Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome
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DOI：
10.1378/chest.122.3.861
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发表时间：
2002-09-01
期刊：
影响因子：
9.6
通讯作者：
Horie, T
中科院分区：
文献类型：
--
作者：
Akashiba, T;Kawahara, S;Horie, T
研究目的：评估严重阻塞性睡眠呼吸暂停（OSAS）患者的生活质量（QOL），以及QOL与OSAS严重程度、白天过度嗜睡（EDS）和情绪之间的关系。方法：采用SF-36量表对60例OSAS患者和34例正常对照组进行生活质量评估，对于EDS使用埃普沃思嗜睡量表（ESS），对于情绪使用Zung自评抑郁量表（SDS）。采用简单回归分析和逐步多元回归分析方法，对SF-36各领域与总分、基线特征、多导睡眠图参数、ESS评分和SDS评分之间的关系进行分析。ESS和SDS评分在患者中也比对照组受损更严重。SF-36各维度与OSAS严重程度及ESS评分无相关性。SF-36的8个领域中有5个领域和总分与SDS评分显著相关。逐步多元回归分析选择三个变量，SDS评分（部分R-2 = 0.505），睡眠期间最低动脉血氧饱和度（部分R-2 = 0.064）和ESS评分（部分R-2 = 0.053），作为预测SF-36总分的独立因素。这三个变量对SF-36总分的总方差贡献率为62.2%（R-2 = 0.622，p < 0.0001）。结论：重度OSAS患者的生活质量较正常对照组下降。经简单回归分析，抑郁量表与患者生活质量呈显著正相关。然而，EDS评分和睡眠期间的氧饱和度下降也影响生活质量，虽然其影响的幅度很小。
Study objectives: To assess the quality of life (QOL) in patients with severe obstructive sleep apnea (OSAS), and the relationship between the QOL and severity of OSAS, excessive daytime sleepiness (EDS), and mood.Methods: Sixty patients with OSAS and 34 normal control subjects were assessed for QOL using the Medical Outcomes Study Short-Form 36 Health Survey questionnaire (SF-36), for EDS using the Epworth sleepiness scale (ESS), and for mood using the Zung self-rated depression scale (SDS). The associations between each domain and the total score on the SF-36 and the baseline characteristics, polysomnographic parameters, ESS score, and SDS score were examined by simple regression analysis and stepwise multiple regression analysis.Results: Six of eight domains and the total score on the SF-36 were significantly lower than those in the control subjects. The ESS and SDS scores were also more impaired in the patients than in the control subjects. There was no relationship between each domain on the SF-36 and the severity of OSAS and ESS score. Five of eight domains and the total score on the SF-36 were significantly correlated with the SDS score. Stepwise multiple regression analysis selected three variables, the SDS score (partial R-2 = 0.505), the lowest arterial oxygen saturation during sleep (partial R-2 = 0.064), and ESS score (partial R-2 = 0.053), as independent factors for predicting the total score on the SF-36. These three variables accounted for 62.2% of the total variance in the total score on SF-36 (R-2 = 0.622, p < 0.0001)Conclusions: The QOL of patients with severe OSAS was decreased compared with normal control subjects. The QOL of patients was strongly correlated with the depression scale on simple regression analysis. However, EDS score and oxygen desaturation during sleep also affected the QOL, although the magnitude of its effect was small.