PROJECTIONS FROM THE LATERAL AND INTERPOSED CEREBELLAR NUCLEI TO THE THALAMUS OF THE RAT - A LIGHT AND ELECTRON-MICROSCOPIC STUDY USING SINGLE AND DOUBLE ANTEROGRADE LABELING
PROJECTIONS FROM THE LATERAL AND INTERPOSED CEREBELLAR NUCLEI TO THE THALAMUS OF THE RAT - A LIGHT AND ELECTRON-MICROSCOPIC STUDY USING SINGLE AND DOUBLE ANTEROGRADE LABELING
复制标题
DOI：
10.1002/cne.903490202
复制
发表时间：
1994-11-08
影响因子：
2.5
通讯作者：
HORNE, MK
中科院分区：
文献类型：
--
作者：
AUMANN, TD;RAWSON, JA;HORNE, MK
小脑外侧核和中间核在控制运动方面可能有不同的功能。来自两个核的输出纤维主要投射到丘脑区域，而丘脑区域又投射到运动皮层。在本研究中，单和双顺行追踪技术已被用于检查和比较大鼠从外侧核和中间核到丘脑的通路，通过使用光镜和电子显微镜来寻找可能构成这些核之间功能差异的组织或结构特征的证据。外侧核末梢位于丘脑内侧，主要位于外侧核腹侧和后核群吻极。后中间核的末梢位于外侧核的略吻侧和外侧，主要位于腹侧外侧核和腹侧后内侧核之间的边界附近。前插核的终末位于后插核的吻侧和外侧，主要位于后插核腹侧的吻侧极。在双顺行示踪实验中也发现来自侧核和插入核的端部在这些主要端部之间的区域不重叠。然而，侧核和中间核的末梢结构以及它们与丘脑神经元的突触关系是相似的。末梢较大，与丘脑神经元近端树突形成突触。它们含有圆形囊泡，并与树突轴和树突棘形成多个突触接触。研究结果表明，来自侧核和中间核的信息在丘脑的不同区域被处理，但两种投射的突触传递到丘脑神经元的模式可能相似。(C) 1994 Wiley-Liss, Inc。
The lateral and interposed cerebellar nuclei may have different functions in the control of movement. Efferent fibres from both nuclei project predominantly to areas of the thalamus, which in turn project to the motor cortex, In this study, single and double anterograde-tracing techniques have been used to examine and compare the pathways from the lateral and interposed nuclei to the thalamus in the rat by using both light and electron microscopy to look for evidence of organisational or structural features that may underlie the proposed functional differences between these nuclei. Terminals from the lateral nucleus were found to be located most medially in the thalamus, predominantly in the ventral lateral nucleus and the rostral pole of the posterior nuclear group.Terminals from the posterior interposed nucleus were located slightly rostral and lateral to those from the lateral nucleus, mainly around the border between the ventral lateral nucleus and the ventral posterior medial nucleus. Terminals from the anterior interposed nucleus were located slightly rostral and lateral to those from the posterior interposed nucleus, predominantly in the rostral pole of the ventral posterior lateral nucleus. Terminals from the lateral and interposed nuclei were also found in double anterograde-tracing experiments to be nonoverlapping in the regions between these main areas of termination. The structure of terminals from the lateral and interposed nuclei, however, as well as their synaptic relationship with thalamic neurones, were found to be similar. The terminals are large and form synapses with proximal dendrites of thalamic neurones. They contained round vesicles and formed multiple synaptic contacts with dendritic shafts, as well as dendritic spines.The findings indicate that information from the lateral and interposed nuclei is processed in separate regions of the thalamus but that the mode of synaptic transfer to thalamic neurones is likely to be similar for the two projections. (C) 1994 Wiley-Liss, Inc.