Limits of radiomic-based entropy as a surrogate of tumor heterogeneity: ROI-area, acquisition protocol and tissue site exert substantial influence.
Limits of radiomic-based entropy as a surrogate of tumor heterogeneity: ROI-area, acquisition protocol and tissue site exert substantial influence.
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DOI：
10.1038/s41598-017-08310-5
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发表时间：
2017-08-11
影响因子：
4.6
通讯作者：
Ferté C
中科院分区：
文献类型：
--
作者：
Dercle L;Ammari S;Bateson M;Durand PB;Haspinger E;Massard C;Jaudet C;Varga A;Deutsch E;Soria JC;Ferté C
熵是一种很有前途的定量成像生物标志物，用于表征癌症成像表型。熵与肿瘤基因表达、肿瘤代谢、肿瘤分期、患者预后和治疗反应有关。我们的假设表明，肿瘤特异性生物标志物，如熵，在同步转移之间应该是相关的。因此，熵方差的显著比例应归因于恶性过程。我们分析了112例匹配/配对同步转移患者（sm# 1和sm# 2），这些患者前瞻性地参加了MOSCATO-01临床试验。使用TexRAD软件从ct扫描划定的感兴趣区域（ROI）提取成像特征。我们发现同步转移熵在5个空间尺度滤波器上是相关的：Spearman的Rho范围在0.41和0.59之间（P = 0.0001， Bonferroni校正）。多变量线性分析显示sm# 1的熵与(1)原发肿瘤类型显著相关；（ii） sm# 2的熵（相同恶性过程）；（iii） ROI面积大小；（iv）转移部位；(v)腰肌（参考组织）的熵。在正常对照组织（主动脉、腰肌）和数学模型中，熵是ROI面积的对数函数（P < 0.01）。我们的结论是，只有当混淆因素得到纠正时，熵才是肿瘤特异性指标。
Entropy is a promising quantitative imaging biomarker for characterizing cancer imaging phenotype. Entropy has been associated with tumor gene expression, tumor metabolism, tumor stage, patient prognosis, and treatment response. Our hypothesis states that tumor-specific biomarkers such as entropy should be correlated between synchronous metastases. Therefore, a significant proportion of the variance of entropy should be attributed to the malignant process. We analyzed 112 patients with matched/paired synchronous metastases (SM#1 and SM#2) prospectively enrolled in the MOSCATO-01 clinical trial. Imaging features were extracted from Regions Of Interest (ROI) delineated on CT-scan using TexRAD software. We showed that synchronous metastasis entropy was correlated across 5 Spatial Scale Filters: Spearman’s Rho ranged between 0.41 and 0.59 (P = 0.0001, Bonferroni correction). Multivariate linear analysis revealed that entropy in SM#1 is significantly associated with (i) primary tumor type; (ii) entropy in SM#2 (same malignant process); (iii) ROI area size; (iv) metastasis site; and (v) entropy in the psoas muscle (reference tissue). Entropy was a logarithmic function of ROI area in normal control tissues (aorta, psoas) and in mathematical models (P < 0.01). We concluded that entropy is a tumor-specific metric only if confounding factors are corrected.
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影响因子：
9.3
作者：
Hatt, Mathieu;Majdoub, Mohamed;Visvikis, Dimitris
通讯作者：
Visvikis, Dimitris
影响因子：
8.4
作者：
Dercle, Laurent;Ammari, Samy;Postel-Vinay, Sophie
通讯作者：
Postel-Vinay, Sophie
影响因子：
45.3
作者：
Choi, Haesun;Charnsangavej, Chuslip;Benjamin, Robert S.
通讯作者：
Benjamin, Robert S.
影响因子：
3.3
作者：
Ganeshan, Balaji;Miles, Kenneth A.;Chatwin, Chris R.
通讯作者：
Chatwin, Chris R.
影响因子：
2.6
作者：
Ganeshan, B.;Skogen, K.;Miles, K.
通讯作者：
Miles, K.