The empirical redefinition of the psychometric criteria for remission in bipolar disorder
The empirical redefinition of the psychometric criteria for remission in bipolar disorder
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DOI：
10.1016/j.jad.2007.06.011
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发表时间：
2008-02-01
影响因子：
6.6
通讯作者：
Tohen, Mauricio
中科院分区：
文献类型：
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作者：
Berk, Michael;Ng, Felicity;Tohen, Mauricio
工作背景：目前对躁狂和双相抑郁缓解的定义是基于常规而非临床的，其临床显著性尚不清楚，因为很少有研究试图根据客观的临床标准对其进行校准。本研究的目的是确定两个广泛使用的临床评定量表，杨氏躁狂量表（YMRS）和蒙哥马利-埃伯格抑郁量表（MADRS），对应于一个客观的全球临床措施缓解在双相情感障碍patients.Methods的等效分数：从四个药理学随机对照试验在双相I障碍进行了分析。两项试验进行了双相抑郁症（N= 4 - 10和833），躁狂或混合发作（N= 136和I-10）和两个。在本研究中，临床总体印象-双极版本（CGI-BP）严重程度评分I（正常，无任何疾病）用作缓解的主要比较指标。分别测定躁狂症和抑郁症研究中与CGI-BP严重程度评分为1相对应的平均总YMRS和MADRS评分。
Background: Current definitions of remission for mania and bipolar depression are convention-rather than empirically-based, and their clinical salience is unclear, as few studies have attempted to calibrate them against objective clinical criteria. This study aimed to determine equivalence scores on two widely used clinical rating scales, the Young Mania Rating Scale (YMRS) and Montgomery-angstrom sberg Depression Rating Scale (MADRS), that corresponded with an objective global clinical measure of remission in bipolar disorder patients.Methods: Data from four pharmacological randomised controlled trials in bipolar I disorder were analysed. Two trials were conducted for bipolar depression (N= 4 10 and 833), and two for manic or mixed episodes (N= 136 and I 10). In this study, a Clinical Global Impression-Bipolar Version (CGI-BP) severity score of I (normal, not at all ill) was used as the primary comparative measure of remission. The mean total YMRS and MADRS scores in the mania and depression studies, respectively, that corresponded with a CGI-BP severity score of 1 were determined.Results: The mean YMRS score that corresponded with a CGI-BP severity score of 1 was