Convergence and divergence in gene expression among natural populations exposed to pollution.
Convergence and divergence in gene expression among natural populations exposed to pollution.
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DOI：
10.1186/1471-2164-8-108
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发表时间：
2007-04-25
期刊：
影响因子：
4.4
通讯作者：
Oleksiak, Marjorie F.
中科院分区：
文献类型：
--
作者：
Fisher, Marla A.;Oleksiak, Marjorie F.
硬骨鱼Fundulus heteroclitus的自然种群耐受广泛的环境条件，包括温度，盐度，缺氧和化学污染物。令人惊讶的是，底栖动物的种群已经适应了被持久性有毒化学物质污染的高度污染的超级基金场地。这些自然种群为发现在复杂的自然环境中进化以应对环境压力的关键基因通路提供了基础。我们使用Fundulus cDNA阵列来比较9个群体中个体大脑中代谢基因的表达模式：3个独立的、污染的超级基金群体和2个遗传相似的、每个超级基金群体的参考群体。我们发现，在这些超级基金人群中，高达17%的代谢基因在基因表达方面发生了适应性变化。在这些基因中，有两个（1.2%）在三个污染种群中表现出保守的反应，这表明这些自然种群中适应环境污染的共同的、独立进化的机制。污染和参考人群之间的显着差异，统计分析表明共享的适应性变化之间的超级基金的人口，并缺乏减少基因表达的变化表明，共同的机制，适应性抵抗人为污染物已经独立地发展在多个底种群。在三个独立的超级基金群体中，两个基因有一个共同的反应，表明高选择压力可能有利于特定的反应。
Natural populations of the teleost fish Fundulus heteroclitus tolerate a broad range of environmental conditions including temperature, salinity, hypoxia and chemical pollutants. Strikingly, populations of Fundulus inhabit and have adapted to highly polluted Superfund sites that are contaminated with persistent toxic chemicals. These natural populations provide a foundation to discover critical gene pathways that have evolved in a complex natural environment in response to environmental stressors. We used Fundulus cDNA arrays to compare metabolic gene expression patterns in the brains of individuals among nine populations: three independent, polluted Superfund populations and two genetically similar, reference populations for each Superfund population. We found that up to 17% of metabolic genes have evolved adaptive changes in gene expression in these Superfund populations. Among these genes, two (1.2%) show a conserved response among three polluted populations, suggesting common, independently evolved mechanisms for adaptation to environmental pollution in these natural populations. Significant differences among individuals between polluted and reference populations, statistical analyses indicating shared adaptive changes among the Superfund populations, and lack of reduction in gene expression variation suggest that common mechanisms of adaptive resistance to anthropogenic pollutants have evolved independently in multiple Fundulus populations. Among three independent, Superfund populations, two genes have a common response indicating that high selective pressures may favor specific responses.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.0508215102
发表时间：
2005-12-27
影响因子：
11.1
作者：
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通讯作者：
Vila, M