The road to transplant tolerance is paved with good dendritic cells.
The road to transplant tolerance is paved with good dendritic cells.
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良好的树突状细胞铺就了移植耐受的道路。
DOI：
10.1002/eji.201343361
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发表时间：
2013
影响因子：
5.4
通讯作者：
Tocco,Georges
中科院分区：
文献类型：
--
作者：
Benichou,Gilles;Tocco,Georges
移植后，受体T细胞可以通过与供体骨髓源性细胞上的MHC II类相互作用（直接同种异体识别）或通过识别与受体抗原呈递细胞上的自身MHC II类分子结合的同种异体肽（间接同种异体识别）来识别供体抗原。通过这两种途径中的任何一种激活促炎性T细胞都会导致同种异体移植排斥反应，因此需要抑制这两种途径才能实现移植耐受。本期《欧洲免疫学杂志》上的一项研究[Eur. J. Immunol.2013.四十三：734-746]显示，修饰为缺乏CD 80/86表达或过表达吲哚胺2，3-双加氧酶（IDO）的同种异体树突细胞（DC）能够抑制小鼠体外和体内的直接和/或间接同种异体应答。值得注意的是，两种同种异体识别途径都被半同种异体DC上自身和同种异体MHC分子的共表达所抑制。本评论讨论了在移植耐受的背景下使用遗传修饰的DC来抑制同种异体反应性的挑战和潜力。
After transplantation, recipient T cells can recognize donor antigens either by interacting with MHC class II on donor bone marrow‐derived cells (direct allorecognition), or by recognizing allogeneic peptides bound to self‐MHC class II molecules on recipient antigen presenting cells (indirect allorecognition). The activation of pro‐inflammatory T cells via either of these pathways leads to allograft rejection, so the suppression of both of these pathways is needed to achieve transplantation tolerance. A study in this issue of theEuropean Journal of Immunology[Eur. J. Immunol. 2013. 43: 734–746] shows that allogeneic dendritic cells (DCs) modified to either lack expression of CD80/86 or over‐express indoleamine 2,3‐dioxygenase (IDO) are able to inhibit direct and/or indirect alloresponses in vitro and in vivo in mice. Notably, both allorecognition pathways were suppressed by the coexpression of self‐ and allo‐MHC molecules on semi‐allogeneic DCs. This Commentary discusses the challenges and potential of using genetically‐modified DCs to suppress alloreactivity in the context of transplant tolerance.