Synthesis and combinational antibacterial study of 5''-modified neomycin.
Synthesis and combinational antibacterial study of 5''-modified neomycin.
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5-修饰新霉素的合成及联合抗菌研究。
DOI：
10.1038/ja.2009.66
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Chang,Cheng-WeiTom
中科院分区：
文献类型：
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作者：
Zhang,Jianjun;Keller,Katherine;Takemoto,JonY;Bensaci,Mekki;Litke,Anthony;Czyryca,PrzemyslawGreg;Chang,Cheng-WeiTom
合成了一个5 ″-修饰的新霉素衍生物库，用于抗菌结构-活性优化策略。两种先导化合物对耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE）都表现出突出的活性。当与其他临床使用的抗生素组合时，测量抗菌活性。观察到显著的协同活性，这可能导致在对抗感染性细菌的战斗中开发新的治疗实践。
A library of 5 ″-modified neomycin derivatives were synthesized for an antibacterial structure–activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed, which may lead to the development of novel therapeutic practices in the battle against infectious bacteria.