Evolution of substrate specificities in the P-type ATPase superfamily
Evolution of substrate specificities in the P-type ATPase superfamily
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DOI：
10.1007/pl00006286
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发表时间：
1998-01-01
影响因子：
3.9
通讯作者：
Palmgren, MG
中科院分区：
文献类型：
--
作者：
Axelsen, KB;Palmgren, MG
P型ATP酶组成了ATP驱动泵的大超家族，其参与带电底物的跨膜转运。我们对159个P型ATP酶的保守核心序列进行了分析。根据底物特异性，而不是根据亲本物种的进化关系，各种ATP酶在五个主要分支中组合在一起，表明新底物特异性的发明伴随着序列进化速率的突然变化。一个迄今未被认识的P型ATP酶家族已被鉴定，预计在真核生物的所有主要门中都有代表。
P-type ATPases make up a large superfamily of ATP-driven pumps involved in the transmembrane transport of charged substrates. We have performed an analysis of conserved core sequences in 159 P-type ATPases. The various ATPases group together in five major branches according to substrate specificity, and not according to the evolutionary relationship of the parental species, indicating that invention of new substrate specificities is accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized family of P-type ATPases has been identified that is expected to be represented in all the major phyla of eukarya.